SynthesisFrontiers in oncology2022
A Systematic Review and Meta-Analysis of Prognostic Nomograms After UTUC Surgery.
Synthesis in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Risk prediction models for ovarian hyperstimulation syndrome: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Serum lactate Dehydrogenase-to-Albumin ratio in upper tract urothelial carcinoma: A promising prognostic biomarker.BMC urology · 2025Article
- Geriatric Nutritional Risk Index as a prognostic marker for predicting survival outcomes in patients with UTUC after radical nephroureterectomy.Scientific reports · 2025Article
- Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery.Open medicine (Warsaw, Poland) · 2025Article
- A multi-data fusion deep learning model for prognostic prediction in upper tract urothelial carcinoma.Frontiers in oncology · 2025Article
- A nomogram for overall survival of second primary cancers following upper-tract urothelial carcinoma: a SEER population-based study.Translational cancer research · 2024Article
- The influence of the initial clinical presentation of upper tract urothelial carcinoma on histopathological tumor features.International urology and nephrology · 2024Article
- Kidney sparing surgery in upper tract urothelial carcinoma: paradigm change in surgical treatment for ureter cancer.Journal of cancer research and clinical oncology · 2023Article
- Upper Tract Urothelial Carcinoma (UTUC) Diagnosis and Risk Stratification: A Comprehensive Review.Cancers · 2023Review
- Minimally Invasive Radical Nephroureterectomy: 5-Year Update of Techniques and Outcomes.Cancers · 2023Review
- Increased urinary B2-microglobulin is associated with poor prognosis of upper tract urothelial carcinoma.Frontiers in oncology · 2022Article
- Risk factors of falls in elderly patients with visual impairment.Frontiers in public health · 2022Article
- What's New in Emergencies, Trauma, and Shock: Nomograms in Emergency Medicine.Journal of emergencies, trauma, and shockArticle
Corrections and comments
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Authors and funding
22 authors at 13 institutions in 13 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Current guidelines recommend assessing the prognosis in high-risk upper tract urothelial carcinoma patients (UTUC) after surgery. However, no specific method is endorsed. Among the various prognostic models, nomograms represent an easy and accurate tool to predict the individual probability for a specific event. Therefore, identifying the best-suited nomogram for each setting seems of great interest to the patient and provider. Objectives: To identify, summarize and compare postoperative UTUC nomograms predicting oncologic outcomes. To estimate the overall performance of the nomograms and identify the most reliable predictors. To create a reference tool for postoperative UTUC nomograms, physicians can use in clinical practice. Design: A systematic review was conducted following the recommendations of Cochrane's Prognosis Methods Group. Medline and EMBASE databases were searched for studies published before December 2021. Nomograms were grouped according to outcome measurements, the purpose of use, and inclusion and exclusion criteria. Random-effects meta-analyses were performed to estimate nomogram group performance and predictor reliability. Reference tables summarizing the nomograms' important characteristics were created. Results: The systematic review identified 26 nomograms. Only four were externally validated. Study heterogeneity was significant, and the overall Risk of Bias (RoB) was high. Nomogram groups predicting overall survival (OS), recurrence-free survival (RFS), and intravesical recurrence (IVR) had moderate discrimination accuracy (c-Index summary estimate with 95% confidence interval [95% CI] and prediction interval [PI] > 0.6). Nomogram groups predicting cancer-specific survival (CSS) had good discrimination accuracy (c-Index summary estimate with 95% CI and PI > 0.7). Advanced pathological tumor stage (≥ pT3) was the most reliable predictor of OS. Pathological tumor stage (≥ pT2), age, and lymphovascular invasion (LVI) were the most reliable predictors of CSS. LVI was the most reliable predictor of RFS. Conclusions: Despite a moderate to good discrimination accuracy, severe heterogeneity discourages the uninformed use of postoperative prognostic UTUC nomograms. For nomograms to become of value in a generalizable population, future research must invest in external validation and assessment of clinical utility. Meanwhile, this systematic review serves as a reference tool for physicians choosing nomograms based on individual needs. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=282596, identifier PROSPERO [CRD42021282596].
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