Evidence map›Paper›PMID 35847834›Full record

ArticleOpen journal of immunology2018

Modeling Macrophage Polarization and Its Effect on Cancer Treatment Success.

Valentin Morales, Luis Soto-Ortiz

Open access · diamondAbstract read
In one paragraph

Article in Open journal of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Valentin MoralesDepartment of Engineering and Technologies, East Los Angeles College, Monterey Park, USA.
Luis Soto-OrtizDepartment of Mathematics, East Los Angeles College, Monterey Park, USA.
East Los Angeles College · US

Funding

BUILD PODER IIRL5GM118975 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI CHAVIRA, GABRIELA, KHACHIKIAN, CRIST SIMON · 2015 to 2023
$10.7M
Project-002UL1GM118976 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI SAETERMOE, CARRIE L · 2015 to 2023
$7.8M
BUILD@CSUNRL5MD009603 · NIMHD · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI CHAVIRA, GABRIELA, KHACHIKIAN, CRIST SIMON · 2014 to 2014
$1.1M
NIGMS NIH HHS RL5 GM118975NIGMS NIH HHS UL1 GM118976NIMHD NIH HHS RL5 MD009603
6 · The paper itself

Abstract

Positive feedback loops drive immune cell polarization toward a pro-tumor phenotype that accentuates immunosuppression and tumor angiogenesis. This phenotypic switch leads to the escape of cancer cells from immune destruction. These positive feedback loops are generated by cytokines such as TGF-

Indexed as

Cancer TherapyFeedback LoopsImmunosuppressionMacrophage PolarizationMathematical Modeling

Identifiers

PMID35847834
PMCPMC9286492
OpenAlexW2811182962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.