Evidence map›Paper›PMID 35847814›Full record

ArticleFrontiers in medicine2022

Characteristics and Genomic Diversity of Measles Virus From Measles Cases With Known Vaccination Status in Shanghai, China.

Xiaoxian Cui, Yunyi Li, Yuying Yang, Wei Tang, Zhi Li, Hongyou Chen, Yang Li, Xinyi Cui, Zhuoying Huang, Xiaodong Sun and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Xiaoxian CuiDivision of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yunyi LiDivision of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yuying YangDivision of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Wei TangDivision of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Zhi LiDepartment of Immunization Program, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Hongyou ChenDivision of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yang LiChongqing School, University of Chinese Academy of Sciences, Chongqing, China.
Xinyi CuiDivision of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Zhuoying HuangDepartment of Immunization Program, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Xiaodong SunDepartment of Immunization Program, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Songtao XuNational Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases, Chinese Center for Disease Control and Prevention, Beijing, China.
Yan ZhangNational Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases, Chinese Center for Disease Control and Prevention, Beijing, China.
Chongshan LiDivision of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Xi ZhangDivision of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Shanghai Municipal Center For Disease Control Prevention · CNNational Institute for Viral Disease Control and Prevention · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the highly effective measles vaccine has dramatically reduced the incidence of measles, measles, and outbreaks continue to occur in individuals who received the measles vaccine because of immunization failure. In this study, patients who have definite records of immunization were enrolled based on measles surveillance in Shanghai, China, from 2009 to 2017, and genomic characteristics regarding viruses retrieved from these cases provided insights into immunization failure. A total of 147 complete genomes of measles virus (MV) were obtained from the laboratory-confirmed cases through Illumina MiSeq. Epidemiological, and genetic characteristics of the MV were focused on information about age, gender, immunization record, variation, and evolution of the whole genome. Furthermore, systematic genomics using phylogeny and selection pressure approaches were analyzed. Our analysis based on the whole genome of 147 isolates revealed 4 clusters: 2 for the genotype H1 (clusters named H1-A, including 73 isolates; H1-B, including 72 isolates) and the other 2 for D8 and B3, respectively. Estimated nucleotide substitution rates of genotype H1 MV derived using genome and individual genes are lower than other genotypes. Our study contributes to global measles epidemiology and proves that whole-genome sequencing was a useful tool for more refined genomic characterization. The conclusion indicates that vaccination may have an effect on virus evolution. However, no major impact was found on the antigenicity in Shanghai isolates.

Indexed as

comparative genomicscomplete genome sequencesgenetic diversitymeasles virusShanghai isolatesvaccine failure

Identifiers

PMID35847814
PMCPMC9281471
OpenAlexW4283724850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.