ReviewOpen access emergency medicine : OAEM2022
Nitroglycerin Use in the Emergency Department: Current Perspectives.
Review in Open access emergency medicine : OAEM, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07059520 (Translesional PRESSURE Measurements to Assess Clinical Relevance of a Mesenteric Artery Stenosis), which is not on this map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Translesional PRESSURE Measurements to Assess Clinical Relevance of a Mesenteric Artery Stenosis (PRESSURE-study)
Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Development, Characterization, and Clinical Evaluation of a 6% Nitroglycerin-Aloe Vera Transdermal Gel for Stable Angina Management.Drug design, development and therapy · 2026Trial
- Cardiovascular Diseases: Exploring Epidemiology, Pathophysiology, Risk Factors, and Medicinal Plant-Based Therapies: A Narrative Review.Health science reports · 2026Article
- Clevidipine versus nitroglycerin for blood pressure control during carotid endarterectomy: a cohort study.BMC anesthesiology · 2025Observational
- Nitroglycerin-Induced Coronary Collapse in a Patient With Myocardial Bridging.JACC. Case reports · 2025Article
- Reply to Letter to the Editor: "Is a Single Nitroglycerin Study Sufficient to Say that It Is Safe Not to Give Nitroglycerin Before Radial Intervention?"Anatolian journal of cardiology · 2025Article
- Can Topical Glyceryl Trinitrate be Effective in the Treatment of Levator Ani Syndrome?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Organ preservation: current limitations and optimization approaches.Frontiers in medicine · 2025Review
- Trinitroglycerine-loaded chitosan nanoparticles attenuate renal ischemia-reperfusion injury by modulating oxidative stress.Scientific reports · 2024Article
- Managing Cluster Headache in Patients with Medical, Psychiatric, and Surgical Comorbidities.Current neurology and neuroscience reports · 2024Review
- Review
- Nose-to-Heart Approach: Unveiling an Alternative Route of Acute Treatment.Biomedicines · 2024Review
- Digital Ischemia in an Extreme Preterm Infant Treated with Nitroglycerin Patch.Case reports in pediatrics · 2024Article
- Semantically oriented EHR navigation with a patient specific knowledge base and a clinical context ontology.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitroglycerin, a fast-acting vasodilator, is commonly used as a first-line agent for angina in the emergency department and to manage chest pain due to acute coronary syndromes. It is also a treatment option for other disease states such as acute heart failure, pulmonary edema, and aortic dissection. Nitroglycerin is converted to nitric oxide, a potent vasodilator, in the body, leading to venodilation at lower dosages and arteriodilation at higher dosages that results in both preload and afterload reduction, respectively. Although nitroglycerin has historically been administered as a sublingual tablet and/or spray, it is often given intravenously in the emergency department as this enables titration to effect with predictable pharmacokinetics. In this review article, we outline the indications, mechanism of action, contraindications, and adverse effects of nitroglycerin as well as review relevant literature and make general recommendations regarding the use of nitroglycerin in the emergency department.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.