Evidence map›Paper›PMID 35847743›Full record

ArticleEJHaem2020

RAS mutation leading to acquired resistance to dabrafenib and trametinib therapy in a multiple myeloma patient harboring BRAF mutation.

Baptiste Le Calvez, Yannick Le Bris, Guillaume Herbreteau, Bastien Jamet, Céline Bossard, Benoit Tessoulin, Thomas Gastinne, Béatrice Mahé, Viviane Dubruille, Nicolas Blin and 7 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in EJHaem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Next-Generation Therapies for Multiple Myeloma.Annual review of cancer biology · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Baptiste Le CalvezDepartment of Hematology University Hospital Nantes France.
Yannick Le BrisHematology Biology University Hospital Nantes France.ORCID https://orcid.org/0000-0002-0095-6999
Guillaume HerbreteauBiochemistry Laboratory University Hospital Nantes France.
Bastien JametDepartment of Nuclear Medicine University Hospital Nantes France.ORCID https://orcid.org/0000-0002-2145-9182
Céline BossardService d'Anatomie et Cytologie Pathologiques, INSERM, CRCINA Université de Nantes, CHU Nantes Nantes F44000 France.
Benoit TessoulinDepartment of Hematology University Hospital Nantes France.ORCID https://orcid.org/0000-0001-7600-3329
Thomas GastinneDepartment of Hematology University Hospital Nantes France.
Béatrice MahéDepartment of Hematology University Hospital Nantes France.
Viviane DubruilleDepartment of Hematology University Hospital Nantes France.
Nicolas BlinDepartment of Hematology University Hospital Nantes France.
Chloé AntierDepartment of Hematology University Hospital Nantes France.
Olivier TheisenHematology Biology University Hospital Nantes France.
Françoise Kraeber-BodéréDepartment of Nuclear Medicine University Hospital Nantes France.
Steven Le GouillDepartment of Hematology University Hospital Nantes France.
Marie C BénéHematology Biology University Hospital Nantes France.
Philippe MoreauDepartment of Hematology University Hospital Nantes France.
Cyrille TouzeauDepartment of Hematology University Hospital Nantes France.ORCID https://orcid.org/0000-0003-0275-2575
Centre Hospitalier Universitaire de Nantes · FRCentre National de la Recherche Scientifique · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma (MM) is still considered incurable and new therapeutic approaches are therefore needed. Deep-sequencing analysis revealed the presence of

Indexed as

BRAFdabrafenibmultiple myelomaRAStrametinib

Identifiers

PMID35847743
PMCPMC9175793
OpenAlexW3045255313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.