Evidence map›Paper›PMID 35847736›Full record

ArticleEJHaem2020

A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom.

Aisling M Flinn, Sheba Macheka, Mary Slatter, Anna-Maria Ewins, Brenda Gibson, Sarah Lawson, Anna Tailby, Giovanna Lucchini, Helen New, Beki James and 3 more

Open access · diamondAbstract read
In one paragraph

Article in EJHaem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Aisling M FlinnDepartment of Paediatric Immunology and Haematopoietic Stem Cell Transplantation Great North Children's Hospital Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0001-9397-0214
Sheba MachekaDepartment of Paediatric Immunology and Haematopoietic Stem Cell Transplantation Great North Children's Hospital Newcastle upon Tyne UK.
Mary SlatterDepartment of Paediatric Immunology and Haematopoietic Stem Cell Transplantation Great North Children's Hospital Newcastle upon Tyne UK.
Anna-Maria EwinsHaematology/Oncology Department The Royal Hospital for Children Glasgow UK.
Brenda GibsonHaematology/Oncology Department The Royal Hospital for Children Glasgow UK.
Sarah LawsonDepartment of Haematology Birmingham Children's Hospital Birmingham UK.
Anna TailbyDepartment of Haematology Birmingham Children's Hospital Birmingham UK.
Giovanna LucchiniBMT Department Great Ormond Street Hospital London UK.
Helen NewNHS Blood and Transplant London Imperial College London UK.
Beki JamesRegional Centre for Paediatric Haematology Leeds Children's Hospital Leeds UK.
Arun AlfredDepartment of Photopheresis Rotherham Foundation Trust Rotherham UK.
Julia ScarisbrickDepartment of Dermatology University Hospital Birmingham Birmingham UK.
Andrew R GenneryDepartment of Paediatric Immunology and Haematopoietic Stem Cell Transplantation Great North Children's Hospital Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0002-6218-1324
Great North Children's Hospital · GBBirmingham Children's Hospital · GBRoyal Hospital for Children · GBGreat Ormond Street Hospital · GBLeeds Teaching Hospitals NHS Trust · GBNHS Blood and Transplant · GBNIHR Surgical Reconstruction and Microbiology Research Centre · GBThe Rotherham NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracorporeal photopheresis (ECP) is a second-line therapy in acute and chronic GVHD and solid organ transplant rejection. We report ECP use in 98 pediatric patients in seven UK centers from 2010 to 2017, the majority treated for aGVHD (73.5%). ECP was safe and well tolerated including in low body weight patients. Most patients were on multiple immunosuppressive therapies prior to ECP; 45.9% were able to reduce or stop immunosuppression with treatment. Complete or partial response was reported in almost 60%. This study supports the need to include ECP treatment data to national transplant databases to provide accurate information regarding service provision, patient outcomes, and safety.

Indexed as

extracorporeal photopheresisGVHDimmunosuppressionpediatricstransplantation

Identifiers

PMID35847736
PMCPMC9175897
OpenAlexW3042678038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.