Evidence map›Paper›PMID 35847688›Full record

ArticleEJHaem2020

Combination of cyclophosphamide and cytarabine as induction regimen for newly diagnosed adult acute myeloid leukemia.

Qingguo Liu, Hongye Gao, Junfan Li, Yimin Hu, Lihua Wu, Xin Zhao, Shangzhu Li

Open access · diamondAbstract read
In one paragraph

Article in EJHaem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qingguo LiuDepartment of Internal Medicine State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020 China.ORCID https://orcid.org/0000-0002-3363-5948
Hongye GaoDepartment of Internal Medicine State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020 China.
Junfan LiDepartment of Internal Medicine State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020 China.
Yimin HuDepartment of Internal Medicine State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020 China.
Lihua WuDepartment of Internal Medicine State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020 China.
Xin ZhaoDepartment of Internal Medicine State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020 China.
Shangzhu LiDepartment of Internal Medicine State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020 China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optimizing the induction therapy of acute myeloid leukemia (AML) may improve the remission rate and reduce the risk of relapse, thereby extend survival. Cyclophosphamide (CTX) shows benefit in treating relapsed and refractory AML patients, but it has not been reported in first-line induction regimens. To assess the efficacy and safety of CTX and moderate-dosage cytarabine (Ara-C) as induction chemotherapy in newly diagnosed adult AML, 40 patients were enrolled to receive CTX (20 mg/kg/d) for 4 consecutive days and Ara-C for 3 (1 g/m

Indexed as

acute myeloid leukemiacyclophosphamidecytarabineinduction chemotherapy

Identifiers

PMID35847688
PMCPMC9176122
OpenAlexW3048802245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.