ArticleFrontiers in aging neuroscience2022
Association of Lesion Location and Fatigue Symptoms After Ischemic Stroke: A VLSM Study.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Neuroimaging correlates of post-stroke fatigue: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Predicting Potential Treatment Targets for Fatigue in Chronic Fatigue Syndrome Using Thalamic Seeding.Brain and behavior · 2026Article
- Profiling disease experience in patients living with brain aneurysms by analyzing multimodal clinical data and quality of life measures.Scientific reports · 2025Article
- Prediction of etiology and prognosis based on hematoma location of spontaneous intracerebral hemorrhage: a multicenter diagnostic study.Neuroradiology · 2025Article
- Post-stroke fatigue - a multidimensional problem or a cluster of disorders? A case for phenotyping post-stroke fatigue.The Journal of physiology · 2025Review
- Post-stroke sensory hypersensitivity: insights from lesion-symptom and disconnection mapping.Brain communications · 2025Article
- From acute neglect to chronic constructional deficits: parietotemporal contributions to long-term post-stroke impairments.Brain communications · 2025Article
- Lesioned hemisphere-specific phenotypes of post-stroke fatigue emerge from motor and mood characteristics in chronic stroke.European journal of neurology · 2024Observational
- A roadmap for research in post-stroke fatigue: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable.International journal of stroke : official journal of the International Stroke Society · 2024Article
- Neuroimaging of neuropsychological disturbances following ischaemic stroke (CONNECT): a prospective cohort study protocol.BMJ open · 2024Article
- A roadmap for research in post-stroke fatigue: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable.Neurorehabilitation and neural repair · 2024Article
- Mechanisms of Post-Stroke Fatigue: A Follow-Up From the Third Stroke Recovery and Rehabilitation Roundtable.Neurorehabilitation and neural repair · 2024Review
- A multicenter clinical nomogram for predicting post-stroke fatigue: development and validation.Frontiers in neurologyArticle
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Poststroke fatigue (PSF) is a common symptom in stroke survivors, yet its anatomical mechanism is unclear. Our study was aimed to identify which brain lesions are related to the PSF in patients with acute stroke. Method: Patients with first-ever acute ischemic stroke consecutively admitted from the first affiliated hospital of the University of Science and Technology of China (USTC) between January 2017 and June 2020. Fatigue was scored using the Fatigue Severity Scale. All the participants were assessed by 3.0 T brain MRI including diffusion-weighted imaging. The infarct lesions were delineated manually and transformed into a standard template. Voxel-based lesion-symptom mapping (VLSM) was applied to investigate the association between lesion location and the occurrence and severity of fatigue. The same analyses were carried out by flipping the left-sided lesions. Multivariate logistic regressions were applied to verify the associations. Results: Of the 361 patients with acute stroke, 142 (39.3%) patients were diagnosed with fatigue in the acute phase and 116 (35.8%) at 6 months after the index stroke. VLSM analysis indicated clusters in the right thalamus which was significantly associated with the occurrence and severity of PSF at 6-month follow-up. In contrast, no significant cluster was found in the acute phase of stroke. The flipped analysis did not alter the results. Multivariate logistic regression verified that lesion load in the right thalamus (OR 2.67, 95% CI 1.46-4.88) was an independent predictor of 6-month PSF. Conclusion: Our findings indicated that lesions in the right thalamus increased the risk of fatigue symptoms 6 months poststroke.
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