Evidence map›Paper›PMID 35847555›Full record

ArticleiScience2022

A metabolic regulatory network for the

Sushila Bhattacharya, Brent B Horowitz, Jingyan Zhang, Xuhang Li, Hefei Zhang, Gabrielle E Giese, Amy D Holdorf, Albertha J M Walhout

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Life science alliance · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sushila BhattacharyaDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Brent B HorowitzDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Jingyan ZhangDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Xuhang LiDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Hefei ZhangDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Gabrielle E GieseDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Amy D HoldorfDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Albertha J M WalhoutDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
University of Massachusetts Chan Medical School · US

Funding

Gene regulatory and metabolic network structure, function and evolutionR35GM122502 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI A. J. Marian Walhout · 2017 to 2026
$8.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIGMS NIH HHS R35 GM122502NIH HHS P40 OD010440
6 · The paper itself

Abstract

Metabolic perturbations can affect gene expression, for instance to rewire metabolism. While numerous efforts have measured gene expression in response to individual metabolic perturbations, methods that determine all metabolic perturbations that affect the expression for a given gene or set of genes have not been available. Here, we use a gene-centered approach to derive a first-pass metabolic regulatory network for

Indexed as

Experimental models in systems biologyMolecular biologySystems biology

Identifiers

PMID35847555
PMCPMC9283940
OpenAlexW4283727715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.