Evidence map›Paper›PMID 35847519›Full record

ArticleActa pharmaceutica Sinica. B2022

Zhong Li, Jimin Xu, Yuekun Lang, Xiangmeng Wu, Saiyang Hu, Subodh Kumar Samrat, Anil M Tharappel, Lili Kuo, David Butler, Yongcheng Song and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  10. [European journal of nuclear medicine and molecular imaging · 2023
    Article
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  12. Potential Therapeutic Effects of Policosanol from Insect Wax on Caenorhabditis elegans Models of Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
    Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Zhong LiDepartment of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
Jimin XuChemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Yuekun LangWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Xiangmeng WuDepartment of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
Saiyang HuWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Subodh Kumar SamratDepartment of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
Anil M TharappelDepartment of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
Lili KuoWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
David ButlerThe Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
Yongcheng SongDepartment of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Qing-Yu ZhangDepartment of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
Jia ZhouChemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Hongmin LiDepartment of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
New York State Department of Health · USThe University of Texas Medical Branch at Galveston · USUniversity of Arizona · USBaylor College of Medicine · USNeural Stem Cell Institute · US

Funding

High throughput screening of orthosteric inhibitors of flavivirus proteaseR01AI131669 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2018 to 2022
$2.6M
High throughput screening of the Prp8 intein splicing inhibitors for pathogenic fungiR01AI140726 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2019 to 2022
$2.4M
High throughput screening of orthosteric inhibitors of flavivirus proteaseR56AI131669 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2017 to 2017
$524k
Neutralizing nanobodies as therapeutics for Dengue virusR21AI140406 · NIAID · WADSWORTH CENTER · PI LAWRENCE, DAVID A, LI, HONGMIN · 2018 to 2019
$460k
Identification and characterization of allosteric inhibitors of Zika protease by targeting the NS2B conformational changeR21AI140491 · NIAID · WADSWORTH CENTER · PI LEMASTER, DAVID M, LI, HONGMIN · 2018 to 2019
$460k
In vivo efficacy studies of existing drugs re-purposed for flaviviruses in mouse modelsR21AI133219 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2017 to 2018
$452k
New Use of Old Drugs for Zika VirusR21AI134568 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2017 to 2018
$447k
Discovery of therapeutics against Cryptococcosis by Repurposing Pharmaceutical LibrariesR21AI141178 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2019 to 2020
$441k
NIAID NIH HHS R01 AI131669NIAID NIH HHS R01 AI140726NIAID NIH HHS R21 AI133219NIAID NIH HHS R21 AI134568NIAID NIH HHS R21 AI140406NIAID NIH HHS R21 AI140491NIAID NIH HHS R21 AI141178NIAID NIH HHS R56 AI131669
6 · The paper itself

Abstract

Zika virus (ZIKV) causes significant human diseases without specific therapy. Previously we found erythrosin B, an FDA-approved food additive, inhibited viral NS2B-NS3 interactions, leading to inhibition of ZIKV infection in cell culture. In this study, we performed pharmacokinetic and

Indexed as

aa, amino acidAntiviralAUC, area under he curveDengue virusDENV, dengue virusDMSO, dimethyl sulfoxidedpi, day post infectionEB, erythrosin BErythrosin BFDA, US Food and Drug AdministrationFlavivirusFRET, fluorescence resonance energy transferip, intraperitonealNS, non-structural proteinORF, open reading framePFU, plaque-forming unitPK, pharmacokineticPP, polyprotein precursorProtease inhibitorSAR, structure−activity relationshipSLC, split luciferase complementationUTR, untranslated regionWHO, World Health OrganizationZika virusZIKV, Zika virus

Identifiers

PMID35847519
PMCPMC9279632
OpenAlexW3210352368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.