Evidence map›Paper›PMID 35847518›Full record

ArticleActa pharmaceutica Sinica. B2022

PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia.

Hsiang-I Tsai, Yanping Wu, Rui Huang, Dandan Su, Yingyi Wu, Xiaoyan Liu, Linglu Wang, Zhanxue Xu, Yuxin Pang, Chong Sun and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. It Takes a Village of Chromatin Remodelers to Regulate rDNA Expression.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Hsiang-I TsaiSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Yanping WuSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Rui HuangDepartment of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.
Dandan SuSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Yingyi WuSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Xiaoyan LiuSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Linglu WangSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Zhanxue XuSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Yuxin PangSchool of Traditional Medicine Materials Resource, Guangdong Pharmaceutical University, Yunfu 527322, China.
Chong SunImmune Regulation in Cancer, German Cancer Research Center, Heidelberg 69120, Germany.
Chao HeSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Fan ShuSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Haitao ZhuDepartment of Medical Imaging, the Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Dongqing WangDepartment of Medical Imaging, the Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Fang ChengSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Laiqiang HuangThe Shenzhen Key Lab of Gene and Antibody Therapy, Center for Biotechnology & Biomedicine, Division of Life and Health Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.
Hongbo ChenSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Sun Yat-sen University · CNJiangsu University · CNGerman Cancer Research Center · DEGuangdong Pharmaceutical University · CNUniversity Town of Shenzhen · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the plant homeodomain-like finger protein 6 (

Indexed as

AMLAML, acute myeloidBFLS, Borjeson–Forssman–Lehmann syndromeChIP, chromatin immunoprecipitationCML, chronic myeloid leukemiaCo-IP, co-immunoprecipitationCX5461DFC, dense fibrillar componentEpigeneticFC, fibrillar centersFUrd, 5-fluorouridineH3K27me1, histone H3 (mono-methyl K27)H3K27me2, histone H3 (di-methyl K27)H3K27me3, histone H3 (tri-methyl K27)H3K9me1, histone H3 (mono-methyl K9)H3K9me2, histone H3 (di-methyl K9)H3K9me3, histone H3 (tri-methyl K9)LeukemiaMethyltransferaseMPAL, mixed-phenotype acute leukemiaNLS, nuclear localization sequencesNoRC, nucleolar chromatin remodeling complexNuRD, nucleosome remodeling and deacetylasePHF6PHF6, plant homeodomain-like finger protein 6pre-rRNA, pre-ribosme RNArDNA, ribosomal DNArDNA transcriptionRe-ChIP, double chromatin immunoprecipitationRNA Pol I, RNA polymerase IrRNA, ribosome RNASUV39H1SUV39H1, suppressor of variegation 3-9 homolog 1T-ALL, T-cell acute lymphoblastic leukemiaUBF1, upstream binding factor 1

Identifiers

PMID35847518
PMCPMC9279718
OpenAlexW3209381361

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.