ArticleAnnals of gastroenterological surgery2022
Safety, efficacy, and operability of a newly developed absorbable adhesion barrier (GM142) in patients with primary rectal cancer scheduled for diverting ileostomy during laparoscopic surgery: Randomized controlled trial.
Article in Annals of gastroenterological surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Cross-Linked Chondroitin Sulfate Adhesion Barrier System in Open Rectal Resection: A Randomized Clinical Trial.JAMA surgery · 2026Trial
- Laparoscopic Surgery Is Associated With Reduced Small Bowel Obstruction Risk After Colorectal Cancer Surgery: A Nationwide Cohort Study of 5458 Patients.Annals of gastroenterological surgery · 2026Article
- Mid-term safety and feasibility of an absorbable gelatin film adhesion barrier after laparoscopic colorectal resection.Annals of medicine and surgery (2012) · 2026Article
- The Functioning of Ethics Committees in Kazakhstan: Results and Recommendations.Materia socio-medica · 2024Article
- Safety, efficacy, and operability of a newly developed absorbable adhesion barrier (GM142) in patients with primary rectal cancer scheduled for diverting ileostomy during laparoscopic surgery: Randomized controlled trial.Annals of gastroenterological surgery · 2022Article
- Well-designed and properly conducted surgical clinical trials: Randomized control trials and big database analyses.Annals of gastroenterological surgery · 2022Article
- Risk Factors for Adhesive Small Bowel Obstruction After Liver Cancer Surgery.Cancer diagnosis & prognosisArticle
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Authors and funding
20 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: The aim of this study was to compare the outcomes of GM142, a newly developed gelatin film with a concave and convex structure to a commercially available conventional film, hyaluronate-carboxymethylcellulose. Methods: Patients with primary rectal cancer who were scheduled for diverting ileostomy during laparoscopic surgery were eligible for this study. Patients were randomized before surgery and an antiadhesion film was applied under the umbilical incision. The primary outcome was the incidence of adhesion under the midline incision confirmed by second-look surgery for diverting ileostomy closure. The secondary outcomes were the adhesion severity score, the extent of adhesion score, the presence of intestinal obstruction, and the success of all patching. Results: A total of 146 patients were enrolled. A total of 123 patients were included in the full analysis set. The primary outcome of "no adhesion" was observed in 66.1% in the GM142 group and 55.7% in the conventional film group. The noninferiority of GM142 to conventional film was confirmed ( Conclusions: The noninferiority of GM142 to conventional film was shown. GM142 showed no major safety issues. The clinical safety profiles of GM142 suggested certain physiological benefits of the gelatin film as an adhesion barrier.
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