Evidence map›Paper›PMID 35846981›Full record

ArticleACS pharmacology & translational science2022

Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants.

Bianca Plouffe, Angeliki Karamitri, Tilman Flock, Jonathan M Gallion, Shane Houston, Carole A Daly, Amélie Bonnefond, Jean-Luc Guillaume, Christian Le Gouill, Phillipe Froguel and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. CHARMM-GUIJournal of chemical theory and computation · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 5 countries.

Bianca PlouffeDepartment of Biochemistry and Molecular Medicine, Université de Montréal, H3T 1J4 Montréal, Québec, Canada.ORCID https://orcid.org/0000-0002-8321-0796
Angeliki KaramitriUniversité de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France.
Tilman FlockLaboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Jonathan M GallionProgram in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, 77030 Houston, Texas, United States.
Shane HoustonThe Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, U.K.
Carole A DalyThe Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, U.K.
Amélie BonnefondUniversité de Lille, INSERM/CNRS UMR 1283/8199-EGID, Institut Pasteur de Lille, CHU de Lille, 59045 Lille, France.
Jean-Luc GuillaumeUniversité de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France.
Christian Le GouillInstitute for Research in Immunology and Cancer, Université de Montréal, H3T 1J4 Montréal, Québec, Canada.
Phillipe FroguelUniversité de Lille, INSERM/CNRS UMR 1283/8199-EGID, Institut Pasteur de Lille, CHU de Lille, 59045 Lille, France.
Olivier LichtargeProgram in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, 77030 Houston, Texas, United States.
Xavier DeupiLaboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.ORCID https://orcid.org/0000-0003-4572-9316
Ralf JockersUniversité de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France.ORCID https://orcid.org/0000-0002-4354-1750
Michel BouvierDepartment of Biochemistry and Molecular Medicine, Université de Montréal, H3T 1J4 Montréal, Québec, Canada.ORCID https://orcid.org/0000-0003-1128-0100
Centre National de la Recherche Scientifique · FRQueen's University Belfast · GBBaylor College of Medicine · USInstitute for Research in Immunology and Cancer · CAPaul Scherrer Institute · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) can engage distinct subsets of signaling pathways, but the structural determinants of this functional selectivity remain elusive. The naturally occurring genetic variants of GPCRs, selectively affecting different pathways, offer an opportunity to explore this phenomenon. We previously identified 40 coding variants of the

Identifiers

PMID35846981
PMCPMC9281605
OpenAlexW4210469131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.