Evidence map›Paper›PMID 35846895›Full record

ArticleNewborn (Clarksville, Md.)

Intestinal Resection is More Likely to be Effective in Necrotizing Enterocolitis Extending to Colon than in Disease Limited to the Small Intestine.

Parvesh M Garg, Jaslyn L Paschal, Katherine Lett, Charles Middleton, Neha Varshney, Akhil Maheshwari

Open access · bronzeAbstract read
In one paragraph

Article in Newborn (Clarksville, Md.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. International Comparison of Surgical Management Practices for Necrotizing Enterocolitis in Neonates: Insights from Cohorts in the Netherlands and Finland.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2025
    Article
  3. AntenatalInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Parvesh M GargDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.ORCID 0000-0001-5949-7304
Jaslyn L PaschalDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Katherine LettDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Charles MiddletonDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Neha VarshneyDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Akhil MaheshwariGlobal Newborn Society, Clarksville, Maryland, United States of America.
University of Mississippi Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
Effect of Platelet Transfusions on Neonatal Intestinal InjuryR01HL133022 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2017 to 2020
$1.6M
Red Cell Transfusion-associated Necrotizing Enterocolitis in Premature InfantsR01HL124078 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL124078NHLBI NIH HHS R01 HL133022NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Background: The prognosis in surgical necrotizing enterocolitis (NEC) has focused on the total length of the resected bowel; the relative impact of small intestinal vs colonic resection is not well studied. Objective: We hypothesized that intestinal resections may reduce mortality and length of hospital stay (LOS) more likely in infants who have NEC extending into the colon than in those with disease limited to the small intestine. We also investigated the relationship between gestational maturation and NEC-related mortality. Methods: A retrospective study of 153 patients compared demographic, clinical, and histopathological information in infants who had NEC limited to the small intestine vs disease with colonic involvement. Results: Our 153 infants had a mean (±standard deviation) gestational age of 27.4 ± 3.4 weeks and a birth weight of 987 ± 505 g. NEC was limited to the small intestine in 103 (67.3%) infants and extended into the colon in 50 (32.7%). Infants with small intestinal NEC needed shorter bowel resections of 28 ± 31.9 cm than 42.2 ± 40.7 cm in those with colonic involvement ( Conclusions: Bowel resections may be more likely associated with shorter LOS in surgical NEC that involves both the small bowel and colon, even when longer segments of the gastrointestinal tract are removed, than in disease limited to the small intestine.

Indexed as

Necrotizing enterocolitisNeonatologyNewborn

Identifiers

PMID35846895
PMCPMC9282977
OpenAlexW4221042544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.