Evidence map›Paper›PMID 35846894›Full record

ArticleNewborn (Clarksville, Md.)

Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis.

Elizabeth Managlia, Xiaocai Yan, Isabelle G De Plaen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Newborn (Clarksville, Md.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  15. Molecular Mechanisms of Hyperoxia-Induced Neonatal Intestinal Injury.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Elizabeth ManagliaDivision of Neonatology, Department of Pediatrics, Ann and Robert H Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States; Center for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Ann and Robert H Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois, United States.
Xiaocai YanDivision of Neonatology, Department of Pediatrics, Ann and Robert H Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States; Center for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Ann and Robert H Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois, United States.
Isabelle G De PlaenDivision of Neonatology, Department of Pediatrics, Ann and Robert H Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States; Center for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Ann and Robert H Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois, United States.
Lurie Children's Hospital · USNorthwestern University · US

Funding

Role of the intestinal microvasculature in necrotizing enterocolitisR01DK116568 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI DE PLAEN, ISABELLE G · 2019 to 2023
$2.7M
NIDDK NIH HHS R01 DK116568
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. NEC is characterized by intestinal tissue inflammation and necrosis. The intestinal barrier is altered in NEC, which potentially contributes to its pathogenesis by promoting intestinal bacterial translocation and stimulating the inflammatory response. In premature infants, many components of the intestinal barrier are immature. This article reviews the different components of the intestinal barrier and how their immaturity contributes to intestinal barrier dysfunction and NEC.

Indexed as

Intestinal barrierNecrotizing enterocolitisPreterm neonate

Identifiers

PMID35846894
PMCPMC9286028
OpenAlexW4221101136

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.