Evidence map›Paper›PMID 35846847›Full record

ReviewBioactive materials2023

Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product.

Xiaolei Guo, Yuan Ma, Yue Min, Jiayi Sun, Xinli Shi, Guobiao Gao, Lei Sun, Jiadao Wang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 59 citations in OpenAlex.

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  20. Polyethersulfone Polymer for Biomedical Applications and Biotechnology.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaolei GuoCenter for Medical Device Evaluation, National Medical Products Administration, Beijing, PR China.
Yuan MaState Key Laboratory of Tribology, Tsinghua University, Beijing, PR China.
Yue MinCenter for Medical Device Evaluation, National Medical Products Administration, Beijing, PR China.
Jiayi SunCenter for Medical Device Evaluation, National Medical Products Administration, Beijing, PR China.
Xinli ShiCenter for Medical Device Evaluation, National Medical Products Administration, Beijing, PR China.
Guobiao GaoCenter for Medical Device Evaluation, National Medical Products Administration, Beijing, PR China.
Lei SunCenter for Medical Device Evaluation, National Medical Products Administration, Beijing, PR China.
Jiadao WangState Key Laboratory of Tribology, Tsinghua University, Beijing, PR China.
National Medical Products Administration · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyaline cartilage plays a critical role in maintaining joint function and pain. However, the lack of blood supply, nerves, and lymphatic vessels greatly limited the self-repair and regeneration of damaged cartilage, giving rise to various tricky issues in medicine. In the past 30 years, numerous treatment techniques and commercial products have been developed and practiced in the clinic for promoting defected cartilage repair and regeneration. Here, the current therapies and their relevant advantages and disadvantages will be summarized, particularly the tissue engineering strategies. Furthermore, the fabrication of tissue-engineered cartilage under research or in the clinic was discussed based on the traid of tissue engineering, that is the materials, seed cells, and bioactive factors. Finally, the commercialized cartilage repair products were listed and the regulatory issues and challenges of tissue-engineered cartilage repair products and clinical application would be reviewed.

Indexed as

Bioactive factorRegulatory challengeScaffoldsStem cellTissue engineering cartilage

Identifiers

PMID35846847
PMCPMC9253051
OpenAlexW4283580988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.