ArticleBioactive materials2023
Carboxymethyl chitosan-alginate enhances bone repair effects of magnesium phosphate bone cement by activating the FAK-Wnt pathway.
Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- HDAC4 regulates hASC osteogenesis and bone regeneration by mediating SMAD4 via histone acetylation.Stem cell reports · 2026Article
- Review
- Article
- Tri-Magnesium Phosphate as a Candidate Biocompatible Retarder for Magnesium Potassium Phosphate Cement: Setting Behavior, Mechanical Properties, and Microstructure.Materials (Basel, Switzerland) · 2026Article
- Engineering a cell wall-deficient protoplast-incorporated hydrogel for infected wound healing.Regenerative biomaterials · 2026Article
- An all-in-one injectable biocement: self-setting magnesium phosphate for bone repair, fracture adhesion and osteoporotic fixation.Regenerative biomaterials · 2026Article
- An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects.Journal of materials science. Materials in medicine · 2025Article
- Biomaterial-based strategies for bone cement: modulating the bone microenvironment and promoting regeneration.Journal of nanobiotechnology · 2025Review
- Versatile application of magnesium-related bone implants in the treatment of bone defects.Materials today. Bio · 2025Review
- Advances in 3D-Printed scaffolds for bone defect repair: material strategies and synergistic functional performance.Frontiers in bioengineering and biotechnology · 2025Review
- Polydopamine/Montmorillonite-Based Brushite Calcium Phosphate Cements: Synergize Mechanical and Osteogenic Capacity for Bone Regeneration.Biomaterials research · 2025Article
- Aligned nanofibers in biomimetic periosteal extracellular matrix/poly(ε-caprolactone) membranes enhance bone regeneration via the ITGB1/PI3K/AKT pathway.Regenerative biomaterials · 2025Article
- Magnesium phosphate functionalized graphene oxide and PLGA composite matrices with enhanced mechanical and osteogenic properties for bone regeneration.Regenerative biomaterials · 2025Article
- A biodegradable magnesium phosphate cement incorporating chitosan and rhBMP-2 designed for bone defect repair.Journal of orthopaedic translation · 2024Article
- Injectable bone cement based on magnesium potassium phosphate and cross-linked alginate hydrogel designed for minimally invasive orthopedic procedures.Scientific reports · 2024Article
- Nanofiber-induced hierarchically-porous magnesium phosphate bone cements accelerate bone regeneration by inhibiting Notch signaling.Bioactive materials · 2024Article
- Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair.Biomedicines · 2024Article
- Comparison of the differentiation of ovine fetal bone-marrow mesenchymal stem cells towards osteocytes on chitosan/alginate/CuO-NPs and chitosan/alginate/FeO-NPs scaffolds.Scientific reports · 2024Article
- Effect of Atmospheric Pressure Plasma Jet Treatments on Magnesium Phosphate Cements: Performance, Characterization, and Applications.ACS biomaterials science & engineering · 2023Article
- Dual-Setting Bone Cement Based On Magnesium Phosphate Modified with Glycol Methacrylate Designed for Biomedical Applications.ACS applied materials & interfaces · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a continuing need for artificial bone substitutes for bone repair and reconstruction, Magnesium phosphate bone cement (MPC) has exceptional degradable properties and exhibits promising biocompatibility. However, its mechanical strength needs improved and its low osteo-inductive potential limits its therapeutic application in bone regeneration. We functionally modified MPC by using a polymeric carboxymethyl chitosan-sodium alginate (CMCS/SA) gel network. This had the advantages of: improved compressive strength, ease of handling, and an optimized interface for bioactive bone in-growth. The new composites with 2% CMCS/SA showed the most favorable physicochemical properties, including mechanical strength, wash-out resistance, setting time, injectable time and heat release. Biologically, the composite promoted the attachment and proliferation of osteoblast cells. It was also found to induce osteogenic differentiation
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.