Evidence map›Paper›PMID 35846790›Full record

ArticleFrontiers in behavioral neuroscience2022

Brain Somatic Variant in Ras-Like Small GTPase

Han Xu, Kai Gao, Qingzhu Liu, Tianshuang Wang, Zhongbin Zhang, Lixin Cai, Ye Wu, Yuwu Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Han XuDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Kai GaoDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Qingzhu LiuChildren Epilepsy Center, Peking University First Hospital, Beijing, China.
Tianshuang WangDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Zhongbin ZhangDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Lixin CaiChildren Epilepsy Center, Peking University First Hospital, Beijing, China.
Ye WuDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Yuwu JiangDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Peking University · CNChinese Institute for Brain Research · CNPeking University First Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: In our group's previous study, we performed deep whole-exome sequencing and targeted amplicon sequencing in the postoperative brain tissue of epilepsy patients with focal cortical dysplasia type II (FCD II). We identified the first somatic variant of Materials and Methods: HEK293T cells were transfected Results: The Conclusion: This study demonstrated for the first time that the somatic gain-of-function variant of

Indexed as

FCD IImTOR pathwaypediatric drug-resistant epilepsyRalAsomatic mutation

Identifiers

PMID35846790
PMCPMC9280360
OpenAlexW4283762435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.