ArticleFrontiers in cellular neuroscience2022
Optimal Technique for Introducing Schwann Cells Into Peripheral Nerve Repair Sites.
Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- A pilot study of the effect of 3D-Schwann-like cells derived from human adipose-derived stem cells on surgery-induced neurogenic bladder.Scientific reports · 2026Article
- Magnetic-topological multistage synergy: Anisotropic ovalbumin scaffolds loaded with magnetically-responsive neural cells for long-distance peripheral nerve regeneration.Bioactive materials · 2026Article
- Few-Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell-Like Phenotypes.Advanced healthcare materials · 2026Article
- Biocompatible, Ion-Conductive Hydrogel-Filled Nerve Conduit for Peripheral Nerve Regeneration.ACS applied materials & interfaces · 2026Article
- Schwann-endothelial crosstalk in neurovascularized cell sheets induced host CGRP release to drive mandibular bone regeneration.Journal of orthopaedic translation · 2026Article
- Injury-specific effect of Schwann cell-derived exosome treatment for peripheral nerve injury.PloS one · 2026Article
- Filamented hydrogels as tunable conduits for guiding neurite outgrowth.Materials today. Bio · 2025Article
- Comparison of cellular-based therapies following a long-segmental peripheral nerve defect in a rat model.PloS one · 2025Article
- Schwann cells in regeneration and cancer.Frontiers in pharmacology · 2025Review
- Schwann Cell-Derived Exosomal Vesicles: A Promising Therapy for the Injured Spinal Cord.International journal of molecular sciences · 2023Review
- Bridging Gaps in Peripheral Nerves: From Current Strategies to Future Perspectives in Conduit Design.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Peripheral nerve injury (PNI) is found in a relatively large portion of trauma patients. If the injury is severe, such as with the presence of a long segmental gap, PNI can present a challenge for treatment. The current clinical standard of nerve harvest for the repair of long segmental gap PNI can lead to many potential complications. While other methods have been utilized, recent evidence indicates the relevance of cell therapies, particularly through the use of Schwann cells, for the treatment of PNI. Schwann cells (SCs) are integral in the regeneration and restoration of function following PNI. SCs are able to dedifferentiate and proliferate, remove myelin and axonal debris, and are supportive in axonal regeneration. Our laboratory has demonstrated that SCs are effective in the treatment of severe PNI when axon guidance channels are utilized. However, in order for this treatment to be effective, optimal techniques for cellular placement must be used. Thus, here we provide relevant background information, preclinical, and clinical evidence for our method in the treatment of severe PNI through the use of SCs and axon guidance channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.