ArticleBio-design and manufacturing2022
In vivo evaluation of additively manufactured multi-layered scaffold for the repair of large osteochondral defects.
Article in Bio-design and manufacturing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Design Strategies to Target Joint Resident Mesenchymal Stem Cells for Osteochondral Regeneration.Cells · 2026Review
- Predicting Cell Differentiation in Mechanically Stimulated Biphasic Osteochondral Scaffolds Using Fluid-Structure Interaction Modelling.Bioengineering (Basel, Switzerland) · 2026Article
- Melt-electrowriting fibrous scaffolds modified with nano-topography structures promoting cardiomyocytes synergistic contraction.Materials today. Bio · 2026Article
- Tissue-specific biosynthesis and spatial distribution of xanthones in Garcinia oblongifolia revealed by integrated metabolomic and full-length transcriptomic analyses.BMC genomics · 2025Article
- Personalized Design of 3D-Printed Osteochondral Scaffold for Osteoarthritis Patients with Different Bone Conditions and Mechanical Evaluation.Bioengineering (Basel, Switzerland) · 2025Article
- Wet-electrospun porous freeform scaffold enhances colonisation of cells.Materials today. Bio · 2025Article
- Biological Reinforced Concrete for Cartilage Repair With 3D Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Biomimetic multizonal scaffolds for the reconstruction of zonal articular cartilage in chondral and osteochondral defects.Bioactive materials · 2025Review
- Review
- Dissecting the Interplay Mechanism among Process Parameters toward the Biofabrication of High-Quality Shapes in Embedded Bioprinting.Advanced functional materials · 2024Article
- A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications.Bio-design and manufacturing · 2024Article
- Osteochondral tissue engineering in translational practice: histological assessments and scoring systems.Frontiers in bioengineering and biotechnology · 2024Review
- Recent development in multizonal scaffolds for osteochondral regeneration.Bioactive materials · 2023Review
- Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications.Biomimetics (Basel, Switzerland) · 2023Review
- Preparation and Characterization of Biomimetic Functional Scaffold with Gradient Structure for Osteochondral Defect Repair.Bioengineering (Basel, Switzerland) · 2023Review
- Height-to-Diameter Ratio and Porosity Strongly Influence Bulk Compressive Mechanical Properties of 3D-Printed Polymer Scaffolds.Polymers · 2022Article
- Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration.Bioengineering (Basel, Switzerland) · 2022Article
- BAMOS project: osteochondral scaffold innovation applied to osteoarthritis.In vitro models · 2022Article
- Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration.Biomaterials translational · 2022Review
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The repair of osteochondral defects is one of the major clinical challenges in orthopaedics. Well-established osteochondral tissue engineering methods have shown promising results for the early treatment of small defects. However, less success has been achieved for the regeneration of large defects, which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the tissue. In this study, we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion techniques. The developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen "sandwich" composite system. The microstructure and mechanical properties of the scaffold were examined, and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle model. The 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen-HAp scaffold, and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage, as demonstrated by hyaline-like cartilage formation. The histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control group. Chondrogenic genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control group. The findings showed the safety and efficacy of the cell-free "translation-ready" osteochondral scaffold, which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects. Graphic abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s42242-021-00177-w.
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