Evidence map›Paper›PMID 35846222›Full record

ArticleEJHaem2022

Rare additional chromosomal abnormalities in acute promyelocytic leukaemia resulting in rapidly fatal disease: report of a case.

Ahmed Maseh Haidary, Sarah Noor, Sahar Noor, Maryam Ahmad, Ahmad Walid Yousufzai, Ramin Saadaat, Zeeshan Ansar Ahmed, Abdul Jamil Rasooli, Ahmad Shekib Zahier, Haider Ali Malakzai and 6 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in EJHaem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Association betweenThe Journal of international medical research · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Ahmed Maseh HaidaryDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.ORCID https://orcid.org/0000-0002-4554-8024
Sarah NoorDepartment of Haemato-Oncology Ali-Abad Teaching Hospital Kabul Afghanistan.
Sahar NoorDepartment of Paediatric Medicine French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.
Maryam AhmadDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.
Ahmad Walid YousufzaiDepartment of Haemato-Oncology Jumhoriat Hospital Kabul Afghanistan.
Ramin SaadaatDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.
Zeeshan Ansar AhmedDepartment of Pathology and Laboratory Services Agha Khan University Karachi Pakistan.
Abdul Jamil RasooliDepartment of Paediatric Medicine French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.
Ahmad Shekib ZahierDepartment of Haemato-Oncology Amiri Medical Complex Kabul Afghanistan.
Haider Ali MalakzaiDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.
Abdul Sami IbrahimkhilDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.
Samuel SharifDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.
Mohammad Sarwar AnwariDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.
Abdul Hadi SaqibDepartment of Pathology and Clinical Laboratory French Medical Institute for Mothers and Children (FMIC) Kabul Afghanistan.
Tawab BaryaliDepartment of Quality French Medical Institute for Mothers and Children Kabul Afghanistan.
Najla NasirDepartment of Internal Medicine Rabia Balkhi Hospital Kabul Afghanistan.
Kabul Medical University · AFKabul University · AFAga Khan University · PKBalkh University · AF

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute promyelocytic leukaemia results from reciprocal translocation between the long arms of chromosomes 15 and 17. This translocation leads to the formation of chimeric gene, which is both the diagnostic marker as well as the therapeutic target of the disease. Additional chromosomal abnormalities are randomly encountered either at diagnosis or during therapy. Here, we present a case of acute promyelocytic leukaemia that had a rare cytogenetic profile at diagnosis. Case presentation: Our patient was a 14-year-old boy, who presented with characteristic clinical and morphological features of acute promyelocytic leukaemia. Karyotypic analysis revealed trisomy of chromosome 8 with deletion of 9p in addition to t(15;17). The patient passed away within the first 8 h of presentation while receiving conventional chemotherapy and haemodynamic resuscitation. Conclusion: Our patient presented with a rare cytogenetic profile and rapidly progressive disease. According to our extensive literature search, this was the first case of acute promyelocytic leukaemia having pathognomonic t(15;17) along with trisomy 8 and 9q deletion.

Indexed as

acute promyelocytic leukaemia (APL)additional chromosomal abnormalities (ACA)fatal diseaserare

Identifiers

PMID35846222
PMCPMC9175789
OpenAlexW3217732101

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.