Evidence map›Paper›PMID 35846176›Full record

ArticleMicrosystems & nanoengineering2022

An acoustofluidic scanning nanoscope using enhanced image stacking and processing.

Geonsoo Jin, Joseph Rich, Jianping Xia, Albert J He, Chenglong Zhao, Tony Jun Huang

Abstract read
In one paragraph

Article in Microsystems & nanoengineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Geonsoo JinThomas Lord Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708 USA.ORCID 0000-0003-4765-4864
Joseph RichDepartment of Biomedical Engineering, Duke University, Durham, NC 27708 USA.
Jianping XiaThomas Lord Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708 USA.ORCID 0000-0001-9902-0228
Albert J HeThomas Lord Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708 USA.
Chenglong ZhaoDepartment of Physics, University of Dayton, 300 College Park, Dayton, OH 45469 USA.
Tony Jun HuangThomas Lord Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708 USA.

Funding

Acoustofluidic Separation of Placental Nanovesicle Subpopulations in Obstetrical DiseasesR01HD103727 · NICHD · STANFORD UNIVERSITY · PI HUANG, TONY JUN, SADOVSKY, YOEL · 2021 to 2025
$2.6M
An acoustofluidic device for diagnosing preclinical Alzheimer's diseaseR44AG063643 · NIA · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2021 to 2022
$2.5M
Development of a digital acoustofluidic system for automating liquid handling in biomedical researchR01GM141055 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2021 to 2024
$1.9M
AFS/SERS Saliva-based SARS-CoV-2 Earliest Infection and Antibodies DetectionU18TR003778 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HUANG, TONY JUN, KIM, YONG · 2021 to 2022
$1.8M
Integrated Acoustofluidic Plasmonic Molecular Diagnostic System for Detecting MicroRNA BiomarkersR01GM135486 · NIGMS · DUKE UNIVERSITY · PI VO-DINH, TUAN · 2020 to 2023
$1.8M
Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and BiofluidsUH3TR002978 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GALL, KENNETH A, HUANG, TONY JUN · 2021 to 2022
$1.8M
Enabling Efficient, Fast, Biocompatible Exosome Separation via AcoustofluidicsR01GM132603 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2019 to 2022
$1.7M
An Acoustofluidic Device for Biocompatible Platelet SeparationR44HL140800 · NHLBI · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2021 to 2022
$1.5M
Three-Dimensional (3D) Acoustofluidic Scanning Nanoscope with Super Resolution and Large Field of ViewR01GM143439 · NIGMS · UNIVERSITY OF DAYTON · PI AGHA, IMAD, HUANG, TONY JUN · 2021 to 2024
$1.5M
NCATS NIH HHS U18 TR003778NCATS NIH HHS UH3 TR002978NHLBI NIH HHS R44 HL140800NIA NIH HHS R44 AG063643NICHD NIH HHS R01 HD103727NIGMS NIH HHS R01 GM132603NIGMS NIH HHS R01 GM135486NIGMS NIH HHS R01 GM141055NIGMS NIH HHS R01 GM143439
6 · The paper itself

Abstract

Nanoscale optical resolution with a large field of view is a critical feature for many research and industry areas, such as semiconductor fabrication, biomedical imaging, and nanoscale material identification. Several scanning microscopes have been developed to resolve the inverse relationship between the resolution and field of view; however, those scanning microscopes still rely upon fluorescence labeling and complex optical systems. To overcome these limitations, we developed a dual-camera acoustofluidic nanoscope with a seamless image merging algorithm (alpha-blending process). This design allows us to precisely image both the sample and the microspheres simultaneously and accurately track the particle path and location. Therefore, the number of images required to capture the entire field of view (200 × 200 μm) by using our acoustofluidic scanning nanoscope is reduced by 55-fold compared with previous designs. Moreover, the image quality is also greatly improved by applying an alpha-blending imaging technique, which is critical for accurately depicting and identifying nanoscale objects or processes. This dual-camera acoustofluidic nanoscope paves the way for enhanced nanoimaging with high resolution and a large field of view.

Indexed as

MicrofluidicsMicro-optics

Identifiers

PMID35846176
PMCPMC9279327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.