Evidence map›Paper›PMID 35846090›Full record

ArticleEJHaem2021

Reduced alpha diversity of the oral microbiome correlates with short progression-free survival in patients with relapsed/refractory multiple myeloma treated with ixazomib-based therapy (AGMT MM 1, phase II trial).

Heinz Ludwig, Bela Hausmann, Martin Schreder, Wolfram Pönisch, Niklas Zojer, Stefan Knop, Eberhard Gunsilius, Alexander Egle, Andreas Petzer, Hermann Einsele and 7 more

Open access · diamondAbstract read
In one paragraph

Article in EJHaem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 4 countries.

Heinz LudwigWilhelminen Cancer Research Institute Vienna Austria.ORCID https://orcid.org/0000-0002-3302-8726
Bela HausmannJoint Microbiome Facility (JMF) Medical University of Vienna & University of Vienna Vienna Austria.
Martin SchrederDivision of Hematology and Medical Oncology Department of Internal Medicine II Würzburg University Medical Center Würzburg Germany.
Wolfram PönischDepartment of Hematology University of Leipzig Leipzig Germany.ORCID https://orcid.org/0000-0002-9666-6274
Niklas ZojerDepartment of Medicine I Wilhelminenspital Vienna Austria.
Stefan KnopDivision of Hematology and Medical Oncology Department of Internal Medicine II Würzburg University Medical Center Würzburg Germany.
Eberhard GunsiliusDepartment of Internal Medicine V Medical University Innsbruck Innsbruck Austria.
Alexander EgleDepartment of Internal Medicine III with Haematology Medical Oncology, Hemostaseology Infectiology and Rheumatology Oncologic Center Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR) Paracelsus Medical University Cancer Cluster Salzburg Salzburg Austria.ORCID https://orcid.org/0000-0003-0648-4416
Andreas PetzerDepartment of Internal Medicine I Ordensklinikum Linz BHS-EKH, Linz Linz Austria.
Hermann EinseleDivision of Hematology and Medical Oncology Department of Internal Medicine II Würzburg University Medical Center Würzburg Germany.
Roman HajekDepartment of Hematooncology University Hospital Ostrava Ostrava Czech Republic.ORCID https://orcid.org/0000-0001-6955-6267
Katja WeiselUniversity of Tübingen Tübingen Germany.
Karl Jochen KrenoszDepartment of Internal Medicine 3 Kepler Universitätsklinikum GmbH Med Campus III Linz Austria.
Alois LangInnere Medizin II LKH Feldkirch Feldkirch Austria.
Daniel LechnerDepartment of Medicine I - Hematology with Stem Cell Transplantation Hemostaseology and Medical Oncology Ordensklinikum Linz Elisabethinen Linz Austria.
Richard GreilDepartment of Internal Medicine III with Haematology Medical Oncology, Hemostaseology Infectiology and Rheumatology Oncologic Center Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR) Paracelsus Medical University Cancer Cluster Salzburg Salzburg Austria.ORCID https://orcid.org/0000-0002-4462-3694
David BerryJoint Microbiome Facility (JMF) Medical University of Vienna & University of Vienna Vienna Austria.
Paracelsus Medical University · ATWilhelminen Hospital · ATInnsbruck Medical University · ATKepler Universitätsklinikum · ATKrankenhaus der Elisabethinen · ATLandeskrankenhaus Feldkirch · ATLeipzig University · DEMedical University of Vienna · ATUniversity of Ostrava · CZUniversity of Tübingen · DEUniversity of Vienna · ATWomen's General Hospital · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in the human microbiome have been linked to several malignant diseases. Here, we investigated the oral microbiome of 79 patients with relapsed/refractory multiple myeloma (MM) treated with ixazomib-thalidomide-dexamethasone. Increased alpha diversity (Shannon index) at the phylum level was associated with longer progression-free survival (PFS) (10.2 vs 8.5 months,

Indexed as

molecular analysismucosalmultiple myeloma

Identifiers

PMID35846090
PMCPMC9176146
OpenAlexW3106536868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.