Evidence map›Paper›PMID 35846050›Full record

ArticleEJHaem2022

Primary central nervous system lymphoma: Inter-compartmental progression.

Vishal Raval, Elaine Binkley, Mary E Aronow, Juan Valenzuela, David M Peereboom, Wei Wei, Sunil Srivastava, Jaqueline Davanzo, Herbert Culver Boldt, Mark P McGarrey and 9 more

Abstract read
In one paragraph

Article in EJHaem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Vishal RavalDepartment of Ophthalmic Oncology Cole Eye Institute Cleveland Clinic Cleveland Ohio USA.
Elaine BinkleyDepartment of Ophthalmology and Visual Sciences University of Iowa Iowa City Iowa USA.
Mary E AronowRetina Service, Massachusetts Eye and Ear Harvard Medical School Boston Massachusetts USA.
Juan ValenzuelaDepartment of Retina and Ophthalmic Oncology Consultores Oftalmológicos Buenos Aires Argentina.
David M PeereboomThe Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center Cleveland Clinic Cleveland Ohio USA.
Wei WeiDepartment of Quantitative Health Sciences Lerner Research Institute Cleveland Clinic Cleveland Ohio USA.
Sunil SrivastavaDepartment of Ophthalmic Oncology Cole Eye Institute Cleveland Clinic Cleveland Ohio USA.
Jaqueline DavanzoDepartment of Ophthalmic Oncology Cole Eye Institute Cleveland Clinic Cleveland Ohio USA.
Herbert Culver BoldtDepartment of Ophthalmology and Visual Sciences University of Iowa Iowa City Iowa USA.
Mark P McGarreyRetina Service, Massachusetts Eye and Ear Harvard Medical School Boston Massachusetts USA.
George N PapaliodisRetina Service, Massachusetts Eye and Ear Harvard Medical School Boston Massachusetts USA.
Lucia SobrinRetina Service, Massachusetts Eye and Ear Harvard Medical School Boston Massachusetts USA.
Ivana K KimRetina Service, Massachusetts Eye and Ear Harvard Medical School Boston Massachusetts USA.
Dimitrios G VavvasRetina Service, Massachusetts Eye and Ear Harvard Medical School Boston Massachusetts USA.
Dean EliottRetina Service, Massachusetts Eye and Ear Harvard Medical School Boston Massachusetts USA.
Lakshmi NayakCenter for Neuro-Oncology Dana-Farber Cancer Institute Boston Massachusetts USA.
Emilio DoddsDepartment of Retina and Ophthalmic Oncology Consultores Oftalmológicos Buenos Aires Argentina.
Francisco Marco Del PontDepartment of neurosurgery Fleni Buenos Aires Argentina.
Arun D SinghDepartment of Ophthalmic Oncology Cole Eye Institute Cleveland Clinic Cleveland Ohio USA.ORCID https://orcid.org/0000-0001-9411-0320

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is limited understanding of the inter-compartmental progression and treatment outcomes of primary central nervous system lymphoma (PCNSL). In this multicenter retrospective cohort study on 234 patients with PCNSL (median age: 62.5 years [18-92]; median follow-up 35 months [0.1-237.0]) from 2000 till 2018 were divided into group 1 (ocular, 44 patients): 1A and 1B without and with CNS progression and group 2 (CNS, 190 patients): 2A and 2B without and with ocular progression, respectively. In group 1 (44 patients), 33 patients received local treatment, and 11 patients received systemic treatment. In group 2 (15 patients), six patients received combination treatment, while seven patients received only systemic treatment. A complete response was observed in 19 (43%) and 91 (48%) patients in groups 1 and 2, respectively. The 2-year progression-free survival (PFS) was 35% (95% CI: 0.23, 0.54) and 56% (95% CI: 0.49, 0.63) for groups 1 and 2, respectively (

Indexed as

inter‐compartmentprimary central nervous system lymphomaprimary central nervous system lymphoma‐ocular variantprimary vitreoretinal lymphomaprogressiontreatment

Identifiers

PMID35846050
PMCPMC9175875

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.