ArticleFrontiers in physiology2022
Heart Rate Variability for the Early Detection of Cardiac Autonomic Dysfunction in Type 1 Diabetes.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 22 citations in OpenAlex.
- Regular postexercise sauna bathing does not improve heart rate variability: A multi-arm randomized controlled trial.Physiological reports · 2025Trial
- Six weeks of high-intensity interval training improve autonomic and metabolic responses in active postmenopausal women.Experimental physiology · 2026Article
- Loss of Nocturnal Dipping in Type 2 Diabetes Mellitus According to Diabetic Kidney Disease: The Role of Vitamin D Levels.Nutrients · 2026Article
- Reduced heart rate variability predicts incident diabetic polyneuropathy.Frontiers in endocrinology · 2026Article
- Development and validation of a nomogram model for predicting cardiac autonomic neuropathy in patients with diabetes.Frontiers in endocrinology · 2026Article
- Sugar slay: a gamified decision support ecosystem for type 1 diabetes.Frontiers in digital health · 2026Article
- The effect of concurrent exercise training (Resistance and Interval Running) and mindful self-compassion therapy on heart rate Variability in type 1 diabetes.Therapeutic advances in endocrinology and metabolism · 2026Article
- Advancing entropy analysis for heart rate variability: clinical insights for aging and diabetes.Frontiers in physiology · 2026Review
- Heart rate variability analysis using electrocardiograms during cardio-ankle vascular index measurement shows good agreement with resting electrocardiogram-based analysis in patients with diabetes: a retrospective cross-sectional study.Diabetology international · 2026Article
- Vitamin D and cardiovascular autonomic neuropathy in type 2 diabetes mellitus according to diabetic kidney disease stage.Frontiers in endocrinology · 2026Article
- Physical Exercise Before Long-Term Electrocardiogram May Enhance the Assessment of Nocturnal Heart Rate Variability in Young Individuals With Type 1 Diabetes Melltius.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2025Article
- Orthostatic test shows higher systolic blood pressure and sympathetic response in uncomplicated type 1 diabetes patients with normal V̇OClinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Effects of insulin-induced hypoglycaemia on cardiac function in people with type 1 and type 2 diabetes and people without diabetes.Diabetes, obesity & metabolism · 2025Article
- Heart rate variability tests for diagnosing cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus in advanced stages of kidney disease.Cardiovascular diabetology · 2025Article
- Recent advances in facilitating the translation of bioelectronic medicine therapies.Current opinion in biomedical engineering · 2025Article
- Utility of nonlinear analysis of heart rate variability in early detection of metabolic syndrome.Frontiers in physiology · 2025Article
- Diabetes alters cardiorespiratory dynamics: insights from short-term recurrence quantification analysis of pulse-respiration quotient.Frontiers in physiology · 2025Article
- Article
- Is fat-to-lean mass ratio a better predictor of heart variability than body mass index?Journal of education and health promotion · 2024Article
- Changes in beat-to-beat blood pressure and pulse rate variability following stroke.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes mellitus (T1DM) has an important impact on morbidity and mortality because it may start early in life. Therefore, the early detection of cardiovascular autonomic neuropathy (DCAN) in T1DM patients is important to intervene quickly and prevent further deterioration. Traditional autonomic function tests detect abnormalities in severely symptomatic patients but they are difficult to be standardized, require the patient's active participation and their sensitivity to the early disease is limited. In comparison, heart rate variability (HRV) is easier to be measured and standardized. Therefore, we aim to find the HRV indexes that better identify DCAN at an early stage in T1DM patients, and evaluate if HRV is a valid alternative to traditional tests. For this aim, we administered the SCOPA-AUT questionnaire on symptoms of autonomic dysfunction as well as deep breathing, Valsalva, handgrip, head-up tilt (HUT), and cold-pressor tests, to 52 T1DM patients and 27 controls. We calculated HRV indexes during supine rest (SUP) and HUT, assessing differences between groups and postures by a linear mixed-effect model for repeated measures. Receiver Operating Characteristic (ROC) analysis quantified how each HRV index and autonomic test distinguishes between patients and controls. We found that the SCOPA-AUT score was slightly but significantly (
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