ArticleFrontiers in physiology2022
Optimal Fenestration of the Fontan Circulation.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- A Digital Model to Explain the Necessity of Prostaglandin E1 After Balloon Atrial Septostomy in D-Transposition of the Great Arteries.Journal of cardiovascular development and disease · 2026Article
- Transcatheter fenestration in Fontan failure: Our clinical experience.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Evaluation of the effects of fenestration in Fontan circulation using a lumped parameter model.The journal of physiological sciences : JPS · 2024Article
- In vitro hemodynamic performance of a blood pump for self-powered venous assist in univentricular hearts.Scientific reports · 2024Article
- In Silico Evaluation of a Self-powered Venous Ejector Pump for Fontan Patients.Cardiovascular engineering and technology · 2023Article
- Narrative review of single ventricle: where are we after 40 years?Translational pediatrics · 2023Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we develop a pulsatile compartmental model of the Fontan circulation and use it to explore the effects of a fenestration added to this physiology. A fenestration is a shunt between the systemic and pulmonary veins that is added either at the time of Fontan conversion or at a later time for the treatment of complications. This shunt increases cardiac output and decreases systemic venous pressure. However, these hemodynamic benefits are achieved at the expense of a decrease in the arterial oxygen saturation. The model developed in this paper incorporates fenestration size as a parameter and describes both blood flow and oxygen transport. It is calibrated to clinical data from Fontan patients, and we use it to study the impact of a fenestration on several hemodynamic variables, including systemic oxygen availability, effective oxygen availability, and systemic venous pressure. In certain scenarios corresponding to high-risk Fontan physiology, we demonstrate the existence of a range of fenestration sizes in which the systemic oxygen availability remains relatively constant while the systemic venous pressure decreases.
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