Evidence map›Paper›PMID 35845995›Full record

ArticleFrontiers in physiology2022

Myosin 5a in the Urinary Bladder: Localization, Splice Variant Expression, and Functional Role in Neurotransmission.

Josephine A Carew, Vivian Cristofaro, Suhas P Dasari, Sean Carey, Raj K Goyal, Maryrose P Sullivan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Josephine A CarewUrology Research, VA Boston Healthcare System, Boston, MA, United States.
Vivian CristofaroUrology Research, VA Boston Healthcare System, Boston, MA, United States.
Suhas P DasariUrology Research, VA Boston Healthcare System, Boston, MA, United States.
Sean CareyUrology Research, VA Boston Healthcare System, Boston, MA, United States.
Raj K GoyalUrology Research, VA Boston Healthcare System, Boston, MA, United States.
Maryrose P SullivanUrology Research, VA Boston Healthcare System, Boston, MA, United States.
VA Boston Healthcare System · USBrigham and Women's Hospital · USHarvard University · US

Funding

Effect of Type II Diabetes on Bladder FunctionI01BX001790 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MARYROSE P SULLIVAN · 2013 to 2026
–
Pathophysiology of Diabetic GastroparesisI01BX002806 · VA · VA BOSTON HEALTH CARE SYSTEM · PI GOYAL, RAJ K · 2016 to 2020
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Dysregulation of Neurotransmission in the Bladder with Parkinson's DiseaseI21BX003680 · VA · VA BOSTON HEALTH CARE SYSTEM · PI SULLIVAN, MARYROSE P · 2017 to 2020
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BLRD VA I01 BX001790BLRD VA I01 BX002806BLRD VA I21 BX003680
6 · The paper itself

Abstract

Dysregulation of neurotransmission is a feature of several prevalent lower urinary tract conditions, but the mechanisms regulating neurotransmitter release in the bladder are not completely understood. The unconventional motor protein, Myosin 5a, transports neurotransmitter-containing synaptic vesicles along actin fibers towards the varicosity membrane, tethering them at the active zone prior to reception of a nerve impulse. Our previous studies indicated that Myosin 5a is expressed and functionally relevant in the peripheral nerves of visceral organs such as the stomach and the

Indexed as

bladder smooth muscleMyosin 5amyosin motorneurotransmissionperipheral nerveprotein splice variants

Identifiers

PMID35845995
PMCPMC9284544
OpenAlexW4283743948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.