SynthesisBioMed research international2022
Periapical Healing following Root Canal Treatment Using Different Endodontic Sealers: A Systematic Review.
Synthesis in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06400030 (The Effects of BioCeramic Sealer With Single Cone Technique on the Healing of Periapical Lesions), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of BioCeramic Sealer With Single Cone Technique on the Healing of Periapical Lesions: A Randomized Controlled Trial
Who cites it
28 citing papers in PubMed.
- Bioceramic versus conventional endodontic sealers: An umbrella review.Journal of conservative dentistry and endodontics · 2026Review
- Surgical management of massive calcium silicate-based sealer extrusion into the maxillary sinus with palatal necrosis in an adolescent.BMC oral health · 2026Article
- Five-year clinical outcomes of root canal treatment using a calcium silicate-based sealer in teeth with apical periodontitis: a retrospective cohort study.Clinical oral investigations · 2026Article
- Physicochemical Characterization and In Vitro Biocompatibility of Epoxy- and Silicone-Based Endodontic Materials.Materials (Basel, Switzerland) · 2026Article
- The "Radicular Tank": A Novel Concept in Endodontics Achieved with the MEA Inverse TaperDentistry journal · 2026Article
- Article
- Resolution of Mental Nerve Paresthesia Associated With a Large Periapical Lesion Following Nonsurgical Endodontic Retreatment: A Case Report With 6-Year Follow-Up.Case reports in dentistry · 2026Article
- Bibliometric Analysis of the Worldwide Scientific Production on Periapical Lesions in Veterinary Medicine: Visualization, Emerging Patterns, and Thematic Evolution.Veterinary medicine international · 2026Article
- Radiographic Outcome of Endodontic Treatment of Teeth with Primary Apical Periodontitis: Results from a Postgraduate Clinic.Dentistry journal · 2025Article
- Periapical Lesion Healing After Retreatment and Root Canal Filling with a Bioceramic-Based Sealer: A Randomized Clinical Study with 1-Year Follow-Up.Journal of clinical medicine · 2025Article
- MTA-Fillapex sealer penetration following activation with various irrigation protocols: a scanning electron microscopy study.Lasers in medical science · 2025Article
- Biocompatibility of Hydraulic Calcium Silicate-Based Cement MTA FlowJournal of functional biomaterials · 2025Article
- Retreatment or replacement of previous endodontically treated premolars with recurrent apical periodontitis? An 8-year historical cohort study.Clinical oral investigations · 2025Article
- Clinical applications and perceptions of bioceramics in endodontics: a cross-sectional survey.Biomaterial investigations in dentistry · 2025Article
- The Immune Regulatory Mechanism of Adrenomedullin on Promoting the Proliferation and Differentiation of Dental Pulp Stem Cells.International dental journal · 2024Article
- Comparative evaluation of postoperative pain and periapical healing after root canal treatment using three different endodontic sealers: A randomized controlled clinical trial.Journal of conservative dentistry and endodontics · 2024Article
- Novel bioactive nanospheres show effective antibacterial effect against multiple endodontic pathogens.Heliyon · 2024Article
- BioceramicHistology and histopathology · 2024Review
- In silico toxicity and immunological interactions of components of calcium silicate-based and epoxy resin-based endodontic sealers.Clinical oral investigations · 2024Article
- Periapical healing outcome following non-surgical endodontic intervention among diabetic patients: A systematic review conducted according to PRISMA guidelines and the Cochrane handbook for systematic reviews of interventions.The Saudi dental journal · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The healing of the periapical tissues is crucial to the success of root canal treatment. The review studies effectively examine various endodontic root canal sealants in terms of periapical healing. This systematic review was formulated following the PRISMA 2020 guidelines and registered in the international prospective register of systematic reviews (PROSPERO) number-CRD42021239192. To find relevant articles, PubMed Central and Medline databases (until February 2022) were searched. Studies that evaluated healing following the application of different endodontic sealers were analysed. A primary outcome measure was the resolution of periapical lesions following the endodontic treatment. In vivo studies comparing radiographic treatment outcomes and articles with a minimum of 6-month follow-up were included. A total of 9 clinical trial studies that met all the inclusion criteria were included in the analysis. The overall risk of bias was high in four studies out of nine studies. Periapical lesions showed significant healing after endodontic treatment regardless of sealer type, although bioceramic and bioactive sealers had shown better results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.