Evidence map›Paper›PMID 35845755›Full record

ArticleArabian journal of chemistry2022

Synthesis and greener pastures biological study of bis-thiadiazoles as potential Covid-19 drug candidates.

Musa A Said, Sayed M Riyadh, Nadia S Al-Kaff, A A Nayl, Khaled D Khalil, Stefan Bräse, Sobhi M Gomha

Open access · goldAbstract read
In one paragraph

Article in Arabian journal of chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Musa A SaidDepartment of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia.
Sayed M RiyadhDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
Nadia S Al-KaffDepartment of Biology, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia.
A A NaylDepartment of Chemistry, College of Science, Jouf University, P.O. Box 2014, Sakaka, Aljouf, Saudi Arabia.
Khaled D KhalilDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
Stefan BräseInstitute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76133 Karlsruhe, Germany.
Sobhi M GomhaDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
Cairo University · EGTaibah University · SAAl Jouf University · SAIslamic University of Madinah · SAKarlsruhe Institute of Technology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of bis- (Abdelhamid et al., 2017, Banerjee et al., 2018, Bharanidharan et al., 2022)thiadiazoles was synthesized from the reaction of precursor dimethyl 2,2'-(1,2-diphenylethane-1,2-diylidene)-bis(hydrazine-1-carbodithioate) and hydrazonyl chlorides in ethanol under ultrasonic irradiation. Spectral tools (IR. NMR, MS, elemental analyses, molecular dynamic simulation, DFT and LUMO and HOMO) were used to elucidate the structure of the isolated products. Molecular docking for the precursor,

Indexed as

Binding energyBis-[1,2,4]thiadiazolesDrug-likeness predictionIvermectinMolecular dockingRemdesivir

Identifiers

PMID35845755
PMCPMC9272579
OpenAlexW4285010763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.