Evidence map›Paper›PMID 35845500›Full record

ArticleAnnals of translational medicine2022

Bortezomib, epirubicin, and dexamethasone (PAD) results in superior free-progression survival compared to bortezomib, cyclophosphamide, and dexamethasone (VCD) treatment in non-transplantation newly diagnosed multiple myeloma patients aged between 50 to 65: a retrospective single-center analysis in non-transplant patients.

Liang Chen, Ke Yi, Hongyan Lan, Yajun Zhang, Simin Jin, Xiaoyu Mou, Hongming Xian, Weijun Fu, Rong Li

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Liang Chen *Nuclear Radiation Injury Protection and Treatment Department, Navy Medical Center of The People's Liberation Army, Shanghai, China.
Ke Yi *Nuclear Radiation Injury Protection and Treatment Department, Navy Medical Center of The People's Liberation Army, Shanghai, China.
Hongyan Lan *Nuclear Radiation Injury Protection and Treatment Department, Navy Medical Center of The People's Liberation Army, Shanghai, China.
Yajun ZhangNuclear Radiation Injury Protection and Treatment Department, Navy Medical Center of The People's Liberation Army, Shanghai, China.
Simin JinNuclear Radiation Injury Protection and Treatment Department, Navy Medical Center of The People's Liberation Army, Shanghai, China.
Xiaoyu MouNuclear Radiation Injury Protection and Treatment Department, Navy Medical Center of The People's Liberation Army, Shanghai, China.
Hongming XianNuclear Radiation Injury Protection and Treatment Department, Navy Medical Center of The People's Liberation Army, Shanghai, China.
Weijun FuMyeloma and Lymphoma Center, Department of Hematology, Chang Zheng Hospital, Navy Medical University, Shanghai, China.
Rong LiNuclear Radiation Injury Protection and Treatment Department, Navy Medical Center of The People's Liberation Army, Shanghai, China.
Shanghai Medical Information Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To explore the optimum induction therapy for patients with newly diagnosed multiple myeloma (NDMM) who are eligible but have not yet received autologous stem cell transplantation (ASCT) in China. Methods: A total of 140 NDMM patients with cytogenetic background were selected from the Chang Zheng Hospital for this study. The induction therapy consisted of combined bortezomib (1.3 mg/m Results: Of the 140 patients enrolled, 56 were treated with VCD and 84 received the PAD regimen. Compared to patients treated with VCD, patients receiving PAD treatment showed better free-progression survival (PFS) (hazard ratio: 0.355; 95% confidence interval: 0.214 to 0.591; P<0.001) and response rates, defined as achieving very good partial response (VGPR) or better (VCD Conclusions: This analysis demonstrated that PAD treatment resulted in better PFS compared to VCD in NDMM patients (aged 50-55 years old) who are eligible for but refuse ASCT therapy.

Indexed as

Chemotherapyclinical cancer researchclinical guidelinessurvival

Identifiers

PMID35845500
PMCPMC9279781
OpenAlexW4285245111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.