ArticleFrontiers in psychiatry2022
Targeted Memory Reactivation During REM Sleep in Patients With Social Anxiety Disorder.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Influencing dreams through sensory stimulation: A systematic review.Sleep medicine reviews · 2024Pooled it
- Could sleep engineering be used to combat PTSD and depression?PLoS biology · 2026Article
- Promoting vocabulary learning during sleep at home using closed-loop targeted memory reactivation.Journal of sleep research · 2025Article
- Anxiety severity in peri-adolescents is associated with greater generalization of negative memories following a period of sleep relative to wake.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Novel psychotherapies for insomnia.Journal of sleep research · 2025Review
- The Future of Non-Invasive Brain Stimulation in Sleep Medicine.Journal of sleep research · 2025Review
- Music-evoked reactivation during continuous perception is associated with enhanced subsequent recall of naturalistic events.bioRxiv : the preprint server for biology · 2025Article
- Targeted memory reactivation during sleep improves emotional memory modulation following imagery rescripting.Translational psychiatry · 2024Article
- An update on recent advances in targeted memory reactivation during sleep.NPJ science of learning · 2024Review
- Overnight neuronal plasticity and adaptation to emotional distress.Nature reviews. Neuroscience · 2024Review
- Article
- Evidence for an emotional adaptive function of dreams: a cross-cultural study.Scientific reports · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Social anxiety disorder (SAD) is characterized by a significant amount of fear when confronted to social situations. Exposure therapy, which is based on fear extinction, does not often lead to full remission. Here, based on evidence showing that rapid eye movement (REM) sleep promotes the consolidation of extinction memory, we used targeted memory reactivation (TMR) during REM sleep to enhance extinction learning in SAD. Methods: Forty-eight subjects with SAD were randomly assigned to two groups: control or TMR group. All patients had two successive exposure therapy sessions in a virtual reality (VR) environment, where they were asked to give a public talk in front of a virtual jury. At the end of each session, and only in the TMR group ( Results: We observed an effect of time on subjective measures of anxiety (SUDS). We did not find any difference in the anxiety levels of the two groups after 1 week of TMR at home. Importantly, the longer the total duration of REM sleep and the more stimulations the TMR group had at home, the less anxious (increased RMSSD) these participants were. Finally, fear in dreams correlated positively with ns-SCRs and SUDS at T3 in the TMR group. Conclusion: TMR during REM sleep did not significantly modulate the beneficial effect of therapy on subjective anxiety. Yet, our results support that REM sleep can contribute to extinction processes and substantiate strong links between emotions in dreams and waking stress levels in these patients.
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