ArticleFrontiers in psychiatry2022
Right Inferior Frontal Activation During Alcohol-Specific Inhibition Increases With Craving and Predicts Drinking Outcome in Alcohol Use Disorder.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Functional magnetic response imaging predictors of alcohol use disorder treatment outcome: a systematic review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Pooled it
- Inhibitory control training and unhealthy behaviours: a meta-analysis testing short and long- term effects in clinical and at-risk populations.Scientific reports · 2026Pooled it
- Cue-Elicited Brain Activity and Treatment Outcomes in Substance Use Disorders: A Meta-Analysis.JAMA network open · 2025Pooled it
- Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct.Psychopharmacology · 2024Pooled it
- Effects of COMT Suppression in a Randomized Trial on the Neural Correlates of Inhibitory Processing Among People With Alcohol Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Trial
- Frontotemporal cortical activity in Chinese male alcohol-dependent patients during a verbal fluency task: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2026Article
- Alcohol Cues Elicit Differences in Brain Activation Patterns of Abstinent Men and Women with Alcohol Use Disorders.Neuropsychiatric disease and treatment · 2026Article
- Brain Connectivity of the Cingulate Cortex in Alcohol Use Disorder: Exploring Its Association With Mindfulness.Addiction biology · 2025Article
- Neural mechanisms underlying cognitive changes in individuals with alcohol use disorder: insights from resting-state functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study.Frontiers in human neuroscience · 2025Article
- Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma.Neuroimage. Reports · 2024Article
- Neurocognitive and neurobehavioral mechanisms of change following psychological treatment for alcohol use disorder.Contemporary clinical trials · 2024Article
- Defining theNature. Mental health · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol use disorder (AUD) is characterized by enhanced cue-reactivity and the opposing control processes being insufficient. The ability to inhibit reactions to alcohol-related cues, alcohol-specific inhibition, is thus crucial to AUD; and trainings strengthening this ability might increase treatment outcome. The present study investigated whether neurophysiological correlates of alcohol-specific inhibition (I) vary with craving, (II) predict drinking outcome in AUD and (III) are modulated by alcohol-specific inhibition training. A total of 45 recently abstinent patients with AUD and 25 controls participated in this study. All participants underwent functional magnetic resonance imaging (fMRI) during a Go-NoGo task with alcohol-related as well as neutral conditions. Patients with AUD additionally participated in a double-blind RCT, where they were randomized to either an alcohol-specific inhibition training or an active control condition (non-specific inhibition training). After the training, patients participated in a second fMRI measurement where the Go-NoGo task was repeated. Percentage of days abstinent was assessed as drinking outcome 3 months after discharge from residential treatment. Whole brain analyses indicated that in the right inferior frontal gyrus (rIFG), activation related to alcohol-specific inhibition varied with craving and predicted drinking outcome at 3-months follow-up. This neurophysiological correlate of alcohol-specific inhibition was however not modulated by the training version. Our results suggest that enhanced rIFG activation during alcohol-specific (compared to neutral) inhibition (I) is needed to inhibit responses when craving is high and (II) fosters sustained abstinence in patients with AUD. As alcohol-specific rIFG activation was not affected by the training, future research might investigate whether potential training effects on neurophysiology are better detectable with other methodological approaches.
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