ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022
The adverse effect of modifiable dementia risk factors on cognition amplifies across the adult lifespan.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Association Between Cognitively Stimulating Activities and Cognitive Function in Older Adults Living in Residential Care Homes.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Regional cerebral arterial elasticity is associated with cardiovascular health in cognitively healthy older adults.bioRxiv : the preprint server for biology · 2026Article
- A Global Burden Perspective on Obstructive Sleep Apnea, Hearing Loss, and Early-Onset Cognitive Decline.Neurology international · 2026Review
- The association between digital literacy and cognitive function in older adults: the multiple mediating roles of self-efficacy, social participation, and psychological resilience.Frontiers in aging · 2026Article
- Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia.Communications medicine · 2025Article
- Modifiable risk factor profiles moderate the effect of β-amyloid pathology on cognition in aging.Neurobiology of aging · 2025Article
- Sex Matters: Association with Superager Classification and Risk Factors.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Cognitive function and speech outcomes after cochlear implantation in older adults.Frontiers in neurology · 2025Article
- Socioeconomic and medical determinants of state-level subjective cognitive decline in the United States.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- APOE ε4 carrier status moderates the effect of lifestyle factors on cognitive reserve.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Hearing loss and its link to cognitive impairment and dementia.Frontiers in dementia · 2023Review
- Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults.Frontiers in aging neuroscience · 2023Article
- The role of cognitive rehabilitation in people with type 2 diabetes: A study protocol for a randomized controlled trial.PloS one · 2023Article
- Demand Coupling Drives Neurodegeneration: A Model of Age-Related Cognitive Decline and Dementia.Cells · 2022Review
- Modifiable risk factors for dementia, and awareness of brain health behaviors: Results from the Five Lives Brain Health Ireland Survey (FLBHIS).Frontiers in psychology · 2022Article
- The adverse effect of modifiable dementia risk factors on cognition amplifies across the adult lifespan.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Sex differences and modifiable dementia risk factors synergistically influence memory over the adult lifespan.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- The relationship between levels of physical activity, adherence to the MIND diet, and cognitive impairment in adults aged 65 years or older in Pakistan.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Reversible lifestyle behaviors (modifiable risk factors) can reduce dementia risk by 40%, but their prevalence and association with cognition throughout the adult lifespan is less well understood. Methods: The associations between the number of modifiable risk factors for dementia (low education, hypertension, hearing loss, traumatic brain injury, alcohol or substance abuse, diabetes, smoking, and depression) and cognition were examined in an online sample ( Findings: Older adults (ages 66-89) had more risk factors than middle-aged (ages 45-65) and younger adults (ages 18-44). Polynomial regression revealed that each additional risk factor was associated with lower cognitive performance (equivalent to 3 years of aging), with a larger association as age increased. People with no risk factors in their forties to seventies showed similar cognitive performance to people 10 or 20 years younger with many risk factors. Interpretation: Modifiable dementia risk factors amplify lifespan age differences in cognitive performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.