Evidence map›Paper›PMID 35845218›Full record

ArticleEJHaem2021

Mechanism of increased efficacy of recombinant Fc-μTP-L309C compared to IVIg to ameliorate mouse immune thrombocytopenia.

Bonnie J B Lewis, Beth Binnington, Megan Blacquiere, Rolf Spirig, Fabian Käsermann, Donald R Branch

Open access · diamondAbstract read
In one paragraph

Article in EJHaem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Bonnie J B LewisDonald R. Branch, BS, MT(ASCP)SBB, PhD Donald R. Branch, BS, MT(ASCP)SBB, PhD 30 Bond Street, Keenan Research Centre Toronto M5B 1W8 Canada.
Beth BinningtonDonald R. Branch, BS, MT(ASCP)SBB, PhD Donald R. Branch, BS, MT(ASCP)SBB, PhD 30 Bond Street, Keenan Research Centre Toronto M5B 1W8 Canada.
Megan BlacquiereDonald R. Branch, BS, MT(ASCP)SBB, PhD Donald R. Branch, BS, MT(ASCP)SBB, PhD 30 Bond Street, Keenan Research Centre Toronto M5B 1W8 Canada.
Rolf SpirigResearch, CSL Biologics Research Center CSL Behring AG Wankdorfstrasse 10 Bern 3010 Switzerland.
Fabian KäsermannResearch, CSL Biologics Research Center CSL Behring AG Wankdorfstrasse 10 Bern 3010 Switzerland.ORCID https://orcid.org/0000-0002-4255-9350
Donald R BranchDonald R. Branch, BS, MT(ASCP)SBB, PhD Donald R. Branch, BS, MT(ASCP)SBB, PhD 30 Bond Street, Keenan Research Centre Toronto M5B 1W8 Canada.ORCID https://orcid.org/0000-0002-8974-2451
CSL (Switzerland) · CHUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombinant Fc-μTP-L309C is more efficacious than intravenous immunoglobulin (IVIg) at ameliorating antibody-mediated autoimmune diseases through its effects on Fcγ receptors (FcγRs). Fc-μTP-L309C inhibited in-vitro FcγR-mediated phagocytosis 10

Indexed as

immune thrombocytopeniaimmunotherapyITPITP intravenous immunoglobulinIVIgIVIGrecombinant Fc hexamer

Identifiers

PMID35845218
PMCPMC9175896
OpenAlexW3203750859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.