ArticleiScience2022
Why do mice squeak? Toward a better understanding of defensive vocalization.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Phylogenomic analysis of vocal fold length evolution reveals links between vocal and auditory systems in terrestrial mammals.Molecular biology and evolution · 2026Article
- Phylogeny and Body Size Predict Distress Call Divergence in Bats: A Comparative Analysis.Animals : an open access journal from MDPI · 2025Article
- Thalamo-hippocampal pathway determines aggression and self-harm.Science advances · 2025Article
- Courtship and distress ultrasonic vocalizations are altered in a mouse model of Angelman syndrome.Journal of neurodevelopmental disorders · 2025Article
- Hidden in plain sound: the scientific potential of house mouse squeaks.Biology letters · 2025Review
- Vocalisations as a potential indicator of parturition in C57BL/6J mice.Animal welfare (South Mimms, England) · 2025Article
- What matters to a mouse? Effects of internal and external context on male vocal response to female squeaks.PloS one · 2025Article
- Developmental encoding of natural sounds in the mouse auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Midbrain neurons important for the production of mouse ultrasonic vocalizations are not required for distress calls.Current biology : CB · 2024Article
- Brainstem control of vocalization and its coordination with respiration.Science (New York, N.Y.) · 2024Article
- The contribution of periaqueductal gray in the regulation of physiological and pathological behaviors.Frontiers in neuroscience · 2024Review
- Audible pain squeaks can mediate emotional contagion across pre-exposed rats with a potential effect of auto-conditioning.Communications biology · 2023Article
- A cholinergic auditory pathway.Nature neuroscience · 2023Article
- Listening to your partner: serotonin increases male responsiveness to female vocal signals in mice.Frontiers in human neuroscience · 2023Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although mice mostly communicate in the ultrasonic range, they also emit audible calls. We demonstrate that mice selectively bred for high anxiety-related behavior (HAB) have a high disposition for emitting sonic calls when caught by the tail. The vocalization was unrelated to pain but sensitive to anxiolytics. As revealed by manganese-enhanced MRI, HAB mice displayed an increased tonic activity of the periaqueductal gray (PAG). Selective inhibition of the dorsolateral PAG not only reduced anxiety-like behavior but also completely abolished sonic vocalization. Calls were emitted at a fundamental frequency of 3.8 kHz, which falls into the hearing range of numerous predators. Indeed, playback of sonic vocalization attracted rats if associated with a stimulus mouse. If played back to HAB mice, sonic calls were repellent in the absence of a conspecific but attractive in their presence. Our data demonstrate that sonic vocalization attracts both predators and conspecifics depending on the context.
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