ArticleFrontiers in cardiovascular medicine2022
High-Intensity Interval Training Improves Cardiac Function by miR-206 Dependent HSP60 Induction in Diabetic Rats.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The effect of high-intensity interval training on health-related outcomes in obese adolescents: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- The effects of high-intensity interval training versus moderate-intensity continuous training on athletes' aerobic endurance performance parameters.European journal of applied physiology · 2024Pooled it
- Protein-enriched intermittent meal replacement combined with moderate-intensity training for weight loss and body composition in overweight women.Scientific reports · 2025Trial
- The role of exercise in modulating NAD+ metabolic enzymes: mechanisms and health benefits.Frontiers in sports and active living · 2026Review
- Effects of short-term bed rest on skeletal muscle function in patients with diabetes mellitus.Journal of diabetes and metabolic disorders · 2025Article
- Efficacy of exercise-based interventions for prediabetes: an umbrella review of meta-analyses of randomised controlled trials.EClinicalMedicine · 2025Article
- Optimal exercise modalities and dose selection to reduce leptin levels in overweight or obese individuals: a network meta-analysis and dose-response relationship study.BMC sports science, medicine & rehabilitation · 2025Article
- LLTH induces white adipose tissue browning via NF κB inhibition in ATM.Scientific reports · 2025Article
- High-intensity interval training improves mitochondrial function and attenuates cardiomyocytes damage in ischemia-reperfusion.International journal of cardiology. Heart & vasculature · 2025Review
- Effects of heat stimulation after high-intensity interval training on serum adipokines, eHSP72, and immunoglobulins in men with obesity.Journal of exercise science and fitness · 2025Article
- miR-320-3p regulates apelin and TGF-β/SMAD3 signaling in hypobaric hypoxia exposed rats to induce skeletal muscle atrophy.Journal of physiology and biochemistry · 2025Article
- Clinical, paraclinical, therapeutic features of acute decompensated heart failure in a Moroccan population.Scientific reports · 2025Article
- Review
- Exercise and dietary interventions in the management of diabetic cardiomyopathy: mechanisms and implications.Cardiovascular diabetology · 2025Review
- Exercise in Diabetic Cardiomyopathy: Its Protective Effects and Molecular Mechanism.International journal of molecular sciences · 2025Review
- The Role of MicroRNA-206 in the Regulation of Diabetic Wound Healing via Hypoxia-Inducible Factor 1-Alpha.Biochemical genetics · 2025Article
- Effects of exercise intensity and diet on cardiac tissue structure and FGF21/β-Klotho signaling in type 2 diabetic mice: a comparative study of HFD and HFD + STZ induced type 2 diabetes models in mice.Diabetology & metabolic syndrome · 2025Article
- MiR-206 may regulate mitochondrial ROS contribute to the progression of Myocardial infarction via TREM1.BMC cardiovascular disorders · 2023Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: A role for microRNAs is implicated in several biological and pathological processes. We investigated the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on molecular markers of diabetic cardiomyopathy in rats. Methods: Eighteen male Wistar rats (260 ± 10 g; aged 8 weeks) with streptozotocin (STZ)-induced type 1 diabetes mellitus (55 mg/kg, IP) were randomly allocated to three groups: control, MICT, and HIIT. The two different training protocols were performed 5 days each week for 5 weeks. Cardiac performance (end-systolic and end-diastolic dimensions, ejection fraction), the expression of miR-206, HSP60, and markers of apoptosis (cleaved PARP and cytochrome C) were determined at the end of the exercise interventions. Results: Both exercise interventions (HIIT and MICT) decreased blood glucose levels and improved cardiac performance, with greater changes in the HIIT group ( Conclusions: Our results indicate that both exercise protocols, HIIT and MICT, have the potential to reduce diabetic cardiomyopathy by modifying the expression of miR-206 and its downstream targets of apoptosis. It seems however that HIIT is even more effective than MICT to modulate these molecular markers.
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Registered trials
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