Evidence map›Paper›PMID 35845006›Full record

ArticleEJHaem2020

Genetic aberrations of

Jay Gunawardana, Justina N Lee, Karolina Bednarska, Valentine Murigneux, Lilia Merida de Long, Muhammed B Sabdia, Simone Birch, Joshua W D Tobin, Maher K Gandhi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJHaem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Targeted Treatment of Follicular Lymphoma.Journal of personalized medicine · 2021
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jay GunawardanaMater Research University of Queensland, Translational Research Institute Brisbane Queensland Australia.ORCID https://orcid.org/0000-0003-2695-3849
Justina N LeeDiamantina Institute University of Queensland Brisbane Queensland Australia.
Karolina BednarskaMater Research University of Queensland, Translational Research Institute Brisbane Queensland Australia.ORCID https://orcid.org/0000-0001-7201-5269
Valentine MurigneuxDiamantina Institute University of Queensland Brisbane Queensland Australia.
Lilia Merida de LongMater Research University of Queensland, Translational Research Institute Brisbane Queensland Australia.
Muhammed B SabdiaMater Research University of Queensland, Translational Research Institute Brisbane Queensland Australia.ORCID https://orcid.org/0000-0003-1977-8878
Simone BirchPrincess Alexandra Hospital Brisbane Queensland Australia.
Joshua W D TobinMater Research University of Queensland, Translational Research Institute Brisbane Queensland Australia.
Maher K GandhiMater Research University of Queensland, Translational Research Institute Brisbane Queensland Australia.ORCID https://orcid.org/0000-0003-1000-5393
Translational Research Institute · AUThe University of Queensland · AUPrincess Alexandra Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma. Twenty to twenty-five percent of FL patients have progression of disease within 24 months. These patients may benefit from immunotherapy if intact antigen presentation is present. Molecular mechanisms impairing major histocompatibility complex class-I (MHC-I) in FL remain undefined. Here, by sequencing of 172 FL tumours, we found the MHC-I transactivator NLRC5 was the most frequent gene abnormality in the MHC-I pathway. Pyrosequencing showed that epigenetic silencing of the

Indexed as

antigen presentationhematological malignanciesimmunotherapynon‐Hodgkin lymphoma

Identifiers

PMID35845006
PMCPMC9176136
OpenAlexW3097982064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.