Evidence map›Paper›PMID 35844993›Full record

ArticleEJHaem2020

Minimal residual disease negativity by next-generation flow in non-CR myeloma patients.

Sung-Min Kim, Naery Euphrasia Yang, Dajeong Jeong, Jiwon Yun, Sohee Ryu, Sung-Soo Yoon, Yong-Oon Ahn, Dong Soon Lee

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJHaem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sung-Min KimCancer Research Institute Seoul National University College of Medicine Seoul South Korea.
Naery Euphrasia YangDepartment of Laboratory Medicine Sejong General Hospital Bucheon Republic of Korea.ORCID https://orcid.org/0000-0001-9359-5848
Dajeong JeongDepartment of Laboratory Medicine Seoul National University Hospital Seoul South Korea.
Jiwon YunDepartment of Laboratory Medicine Seoul National University Hospital Seoul South Korea.
Sohee RyuDepartment of Laboratory Medicine Seoul National University Hospital Seoul South Korea.
Sung-Soo YoonDepartment of Internal Medicine Seoul National University College of Medicine Seoul South Korea.
Yong-Oon AhnCancer Research Institute Seoul National University College of Medicine Seoul South Korea.
Dong Soon LeeCancer Research Institute Seoul National University College of Medicine Seoul South Korea.
Seoul National University · KRSeoul National University Hospital · KRSejong General Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Next-generation flow (NGF) has detected minimal residual disease (MRD) in numerous myeloma patients who achieve a complete response (CR). However, when MRD is not detected via NGF in non-CR patients, its clinical meaning is uncertain. Here, we investigated the correlation between MRD findings on NGF and the response criteria, paying special attention to patients with discrepant results. We performed NGS analysis of IgH rearrangements on bone marrow samples from the non-CR patients with negative MRD on NGF. NGS detected residual abnormal clones in those patients, suggesting that NGF and NGS should be used in a complementary manner for MRD investigation.

Indexed as

MRD (minimal residual disease)MyelomaNGF (next‐generation flow)

Identifiers

PMID35844993
PMCPMC9175670
OpenAlexW3088607477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.