Evidence map›Paper›PMID 35844823›Full record

ArticleHealth science reports2022

Effect of low dose acetylsalicylic acid and anticoagulant on clinical outcomes in COVID-19, analytical cross-sectional study.

Muhammad B Malik, Samar A Amer, Eric Merrell, Ronald Russo, Jeffrey B Riley, Austin Scro, Elizabeth James, Anderson Anuforo, Soumya Adhikari, Rosalie Siciliano and 6 more

Open access · goldAbstract read
In one paragraph

Article in Health science reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Muhammad B MalikDepartment of Medicine SUNY Upstate Medical University Syracuse New York USA.ORCID https://orcid.org/0000-0002-9493-6226
Samar A AmerDepartment of Public Health and Community Medicine Zagazig Medical University Zagazig Egypt.ORCID https://orcid.org/0000-0002-9475-6372
Eric MerrellDepartment of Medicine SUNY Upstate Medical University Syracuse New York USA.
Ronald RussoDepartment of Medicine SUNY Upstate Medical University Syracuse New York USA.
Jeffrey B RileyCardiovascular Perfusion College of Health Professions SUNY Upstate Medical University Syracuse New York USA.
Austin ScroSUNY Upstate Medical University Syracuse New York USA.ORCID https://orcid.org/0000-0003-4238-6231
Elizabeth JamesSUNY Upstate Medical University Syracuse New York USA.
Anderson AnuforoDepartment of Medicine SUNY Upstate Medical University Syracuse New York USA.
Soumya AdhikariDepartment of Medicine SUNY Upstate Medical University Syracuse New York USA.
Rosalie SicilianoSUNY Upstate Medical University Syracuse New York USA.
Philip ChebayaDepartment of Medicine SUNY Upstate Medical University Syracuse New York USA.
Edward DarlingCardiovascular Perfusion College of Health Professions SUNY Upstate Medical University Syracuse New York USA.
Michael KuhnDepartment of Medicine SUNY Upstate Medical University Syracuse New York USA.
Gary NiemanDepartment of Surgery SUNY Upstate Medical University Syracuse New York USA.
Ahmed ShawkatDepartment of Pulmonary and Critical Care SUNY Upstate Medical University Syracuse New York USA.
Hani AiashDepartment of Medicine SUNY Upstate Medical University Syracuse New York USA.
SUNY Upstate Medical University · USSuez Canal University · EGZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: The therapeutic strategy for the treatment of known sequelae of COVID-19 has shifted from reactive to preventative. In this study, we aim to evaluate the effects of acetylsalicylic acid (ASA), and anticoagulants on COVID-19 related morbidity and mortality. Methods: This record-based analytical cross-sectional study targeted 539 COVID-19 patients in a single United States medical center between March and December 2020. Through a random stratified sample, we recruited outpatient ( Results: Age, mean number of comorbidities, and all individual comorbidities except for asthma, and malignancy were significantly lower in the SC compared to ASA and AC. After adjusting for age and comorbidity via binary logistic regression models, no statistical differences were found between groups for the studied outcomes. When compared to the SC group, ASA had lower 30-day readmission rates (odds ration [OR] 0.81 95% confidence interval [CI] 0.35-1.88, Conclusion: Low-dose ASA has a nonsignificant but potentially protective role in reducing the risk of COVID-19 related morbidity and mortality. Our data suggests a trend toward reduced 30-day readmission rates, ARDS, MICU admissions, need for mechanical ventilation, and mortality compared to the standard management protocol. Further randomized control trials are needed to establish causal effects.

Indexed as

acetylsalicylic acidanticoagulationASACOVID‐19preventative medicine

Identifiers

PMID35844823
PMCPMC9273938
OpenAlexW4285019799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.