SynthesisFrontiers in pediatrics2022
The Effect of Vitamin D Supplementation in Children With Asthma: A Meta-Analysis.
Synthesis in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 8 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Pooled it
- The Role of Vitamin D in Severity and Control of Asthma in Children and Adolescents: A Systematic Review and Meta-Analysis.Pediatric pulmonology · 2026Pooled it
- Efficacy and safety of vitamin D in the treatment of asthma: an overview of systematic reviews and meta-analyses.Frontiers in medicine · 2026Pooled it
- The efficacy of vitamin D supplementation in the management of childhood asthma: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.Annals of medicine · 2024Pooled it
- Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Pooled it
- Relationship between vitamin D and asthma from gestational to adulthood period: a meta-analysis of randomized clinical trials.BMC pulmonary medicine · 2023Pooled it
- Vitamin D for the management of asthma.The Cochrane database of systematic reviews · 2023Pooled it
- Micronutrients in Pediatric Asthma: Biological Mechanisms and Clinical Evidence-A Narrative Review.Nutrients · 2026Review
- Nutrition as a Modifiable Factor in Optimizing Respiratory Health: Evidence from Pulmonary Function Tests.Children (Basel, Switzerland) · 2026Review
- Integrative analysis of vitamin D, ferritin, and eosinophilic inflammation in predicting acute exacerbations of childhood asthma.Frontiers in immunology · 2026Article
- Vitamin D exerts endogenous control over TiScience · 2025Article
- Vitamin D deficiency and asthma morbidity in school-age children: a single-center cohort study.Frontiers in public health · 2025Article
- Safety Profile of Vitamin D in Italy: An Analysis of Spontaneous Reports of Adverse Reactions Related to Drugs and Food Supplements.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: An increasing number of studies have suggested that vitamin D can be used to treat childhood asthma, but its clinical effects are still unclear. We conducted this meta-analysis to examine the latest estimates of the effectiveness and safety of using vitamin D to treat childhood asthma. Methods: The PubMed, The Cochrane Library, ScienceDirect, Embase, Scopus, Ovid MEDLINE, Web of Science, and Google Scholar databases were searched for randomized controlled trials (RCTs) describing vitamin D supplementation interventions for asthmatic children. Asthma exacerbation, vitamin D levels, the predicted percentage of forced expiratory volume in the first second (FEV1%) and adverse effects (AEs) were analyzed as the main outcome measures. Results: After screening, eight RCTs with 738 children were included. Compared with placebos, vitamin D supplementation had a stronger effect on serum vitamin D levels [mean difference (MD) = 13.51 (4.24, 22.79), Conclusions: Vitamin D supplementation significantly increased patients' serum vitamin D levels, but it had no benefit for asthma control. However, vitamin D supplementation might reduce patients' lung function. It is essential to systemically search for more large-scale, rigorous, and well-designed RCTs to fully confirm these conclusions. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021288838, PROSPERO CRD42021288838.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.