Evidence map›Paper›PMID 35844604›Full record

ReviewFrontiers in immunology2022

Natural Killer Cells in SARS-CoV-2 Infection: Pathophysiology and Therapeutic Implications.

Clara Di Vito, Francesca Calcaterra, Nicolò Coianiz, Sara Terzoli, Antonio Voza, Joanna Mikulak, Silvia Della Bella, Domenico Mavilio

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Clara Di VitoUnit of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.
Francesca CalcaterraUnit of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.
Nicolò CoianizUnit of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.
Sara TerzoliUnit of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.
Antonio VozaDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Joanna MikulakUnit of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.
Silvia Della BellaUnit of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.
Domenico MavilioUnit of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the control of viral infections in the absence of a prior antigen sensitization. Indeed, they display rapid effector functions against target cells with the capability of direct cell killing and antibody-dependent cell-mediated cytotoxicity. Furthermore, NK cells are endowed with immune-modulatory functions innate and adaptive immune responses

Indexed as

COVID-19HumansImmunity, InnateKiller Cells, NaturalPandemicsSARS-CoV-2COVID-19immunotherapymemory-likeNK cellsSARS-CoV-2 infectionsingle cell sequencing

Identifiers

PMID35844604
PMCPMC9279859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.