Evidence map›Paper›PMID 35844549›Full record

ArticleFrontiers in immunology2022

Altered Balance of Pro-Inflammatory Immune Cells to T Regulatory Cells Differentiates Symptomatic From Asymptomatic Individuals With Anti-Nuclear Antibodies.

Rashi Gupta, Emma Vanlieshout, Kieran Manion, Dennisse Bonilla, Michael Kim, Carolina Muñoz-Grajales, Carol Nassar, Sindhu R Johnson, Linda T Hiraki, Zareen Ahmad and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Advanced Autoantibody Testing in Systemic Sclerosis.Diagnostics (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Rashi GuptaDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Emma VanlieshoutDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Kieran ManionSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Dennisse BonillaSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Michael KimSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Carolina Muñoz-GrajalesDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Carol NassarDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Sindhu R JohnsonDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
Linda T HirakiThe Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
Zareen AhmadDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
Zahi ToumaDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
Arthur BookmanDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
Joan E WitherDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
University of Toronto · CAKrembil Research InstituteUniversity Health Network · CAArthritis Society · CAMount Sinai Hospital · CA

Funding

CIHR
6 · The paper itself

Abstract

Systemic Autoimmune Rheumatic Diseases (SARDs) are characterized by the production of anti-nuclear antibodies (ANAs). ANAs are also seen in healthy individuals and can be detected years before disease onset in SARD. Both the immunological changes that promote development of clinical symptoms in SARD and those that prevent autoimmunity in asymptomatic ANA

Indexed as

Autoimmune DiseasesRheumatic DiseasesAntibodies, AntinuclearAutoimmunityHumansT-Lymphocytes, RegulatoryAntibodies, Antinuclearanti-nuclear antibodiesb cellsdendritic cellsinterferon-alphamonocytessystemic autoimmune rheumatic diseasest cellst regulatory cells

Identifiers

PMID35844549
PMCPMC9279569
OpenAlexW4283737665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.