Evidence map›Paper›PMID 35844407›Full record

ArticleSaudi journal of biological sciences2022

Subacute toxic effects of silver nanoparticles oral administration and withdrawal on the structure and function of adult Albino Rats' hepatic tissue.

Shimaa Mohammad Yousof, Horeya Erfan, Marwa Mohamed Hosny, Shaimaa A Shehata, Karima El-Sayed

Abstract read
In one paragraph

Article in Saudi journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Multifactorial Role of Phytogenic CeOPlant-environment interactions (Hoboken, N.J.) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shimaa Mohammad YousofDepartment of Medical Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Horeya ErfanDepartment of Histology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Marwa Mohamed HosnyDepartment of Medical Biochemistry and Molecular Biology as well as Oncology Diagnostic Unit, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Shaimaa A ShehataDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Karima El-SayedDepartment of Medical Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Products containing Silver nanoparticles (Ag NPs) are becoming vastly used in our daily life. The widespread increased introduction of Ag NPs in many aspects of life has raised researchers' concerns regarding their safety and toxicity for biological and environmental life in the past few years. The current study aimed to explore the subsequent effects of Ag NPs withdrawal, following short-term oral administration. Eighteen rats were assigned randomly into three groups (control group "1" and AG NPs treated groups "2" and "3"; 6 animals each). The control group received normal food and tap water while groups 2 & 3 received 0.5 ml of a solution containing 25 ppm Ag NPs for 14 days. Group 2 rats were sacrificed on day 14 whereas group 3 was left for another 14 days of particle cessation followed by euthanasia on day 28. Functional assessment was done by liver enzyme assays, hydrogen peroxide activity, hepatic

Indexed as

Ag NPs, Silver NanoparticlesALT, Alanine TransaminaseAST, Aspartate TransaminaseBdnf, Brain-derived neurotrophic factorH2o2, Hydrogen PeroxideHCC, Hepatocellular CarcinomaH&E, Hematoxylin & Eosin stainHepatic BdnfHepatotoxicityHydrogen peroxideLiver enzymesMasson's trichrome stainsNaBH4, Sodium BorohydrideNanoparticles, (NPs)PAS, Periodic acid-Schiffppm, Parts Per MillionPVP, Polyvinyl PyrrolidoneRNA, Ribonucleic acidROS, Reactive Oxygen SpeciesSGOT, Serum Glutamate oxaloacetate TransaminaseSGPT, Serum Glutamate pyruvate TransaminaseSilver Nanoparticles (Ag NPs)TEM, Transmission Electron MicroscopyTransmission Electron MicroscopyTRI, Masson's trichrome stainsUltraviolet–Visible SpectroscopyUV–Vis, Ultraviolet–Visible Spectroscopy

Identifiers

PMID35844407
PMCPMC9280256

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.