Evidence map›Paper›PMID 35844082›Full record

ArticlePediatric transplantation2022

Immediate extubation following pediatric liver transplantation.

Dor Yoeli, Thanh Nguyen, Matthew Wilder, Joy Huang, Sheila Pahlavan, Dania Brigham, Shikha S Sundaram, Michael E Wachs, Megan A Adams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dor YoeliDivision of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, USA.ORCID 0000-0001-6993-255X
Thanh NguyenDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, USA.
Matthew WilderDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, USA.
Joy HuangSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Sheila PahlavanSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Dania BrighamSection of Gastroenterology, Hepatology and Nutrition, The Digestive Health Institute, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
Shikha S SundaramSection of Gastroenterology, Hepatology and Nutrition, The Digestive Health Institute, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
Michael E WachsDivision of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, USA.
Megan A AdamsDivision of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, USA.ORCID 0000-0002-0148-1593

Funding

NRSA Training CoreTL1TR002533 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CICUTTO, LISA · 2018 to 2022
$3.0M
NCATS NIH HHS TL1 TR002533
6 · The paper itself

Abstract

backgroundImmediate extubation (IE) following pediatric liver transplantation is being increasingly performed. The aim of this study was to characterize the rate of IE at our institution and identify recipient factors predictive of IE.

methodsAll pediatric liver transplants performed at our institution between January 1, 2015 and December 31, 2020 were reviewed. Retransplants and multi-organ transplants were excluded. IE was defined as extubation in the operating room following transplant. Backward stepwise logistic regression at a p-value threshold of .05 was performed to identify variables associated with IE.

resultsIE was achieved in 58 (72%) of the 81 pediatric liver transplants. The IE cohort had significantly shorter ICU length of stay and overall hospital length of stay, though IE was not an independent predictor of posttransplant length of stay. Age <2 years, preoperative mechanical ventilation, and total intraoperative epinephrine and dopamine infusion requirements were significant, independent risk factors against IE. This multivariable model was highly predictive of IE (area under the curve = 0.89).

conclusionsWe describe the highest rate of IE postpediatric liver transplantation that has been reported to date and identified significant risk factors against successful IE.

Indexed as

Airway ExtubationLiver TransplantationChildChild, PreschoolHumansLength of StayRespiration, ArtificialRetrospective Studiesanesthesiacomplicationsgraft survivalliver transplantation

Identifiers

PMID35844082
PMCPMC12866978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.