Evidence map›Paper›PMID 35843943›Full record

Trial reportJournal of neuroengineering and rehabilitation2022

Intermittent theta burst stimulation modulates biceps brachii corticomotor excitability in individuals with tetraplegia.

Neil Mittal, Blaize C Majdic, Carrie L Peterson

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03277521 (Intermittent Theta Burst Stimulation to Promote Motor Re-education After Upper Limb Reconstruction in Tetraplegia), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03277521 nacompletednot on this map

Intermittent Theta Burst Stimulation to Promote Motor Re-education After Upper Limb Reconstruction in Tetraplegia

TypeinterventionalSponsorVirginia Commonwealth UniversityRan2018 to 2020Enrolled19ConditionsQuadriplegia/TetraplegiaArmsIntermittent theta burst stimulation
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Neil MittalBiomedical Engineering, College of Engineering, Rehabilitation Engineering to Advance Ability Lab, Virginia Commonwealth University, Biotech Eight, 737 N 5th Street, Richmond, VA, 23219, USA.ORCID 0000-0002-2000-9841
Blaize C MajdicBiomedical Engineering, College of Engineering, Rehabilitation Engineering to Advance Ability Lab, Virginia Commonwealth University, Biotech Eight, 737 N 5th Street, Richmond, VA, 23219, USA.ORCID 0000-0001-8768-4297
Carrie L PetersonBiomedical Engineering, College of Engineering, Rehabilitation Engineering to Advance Ability Lab, Virginia Commonwealth University, Biotech Eight, 737 N 5th Street, Richmond, VA, 23219, USA. clpeterson@vcu.edu.ORCID 0000-0002-7169-2089
Virginia Commonwealth University · US

Funding

Techniques DevelopmentP2CHD086844 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GEORGE, MARK S · 2015 to 2024
$12.7M
NICHD NIH HHS P2C HD086844NIH HHS P2CHD0886844
6 · The paper itself

Abstract

backgroundIntermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation (TMS) that can increase corticomotor excitability of hand muscles in individuals with spinal cord injury (SCI). The objective of this study was to determine the effect of iTBS on the corticomotor excitability of the biceps brachii in individuals with tetraplegia.

methodsTen individuals with low cervical SCI (C5-C8) and ten nonimpaired individuals completed three independent sessions. Motor evoked potentials (MEPs) served as our measure of corticomotor excitability and were collected before and after iTBS. MEPs were normalized by the electromyography corresponding to maximum voluntary contraction and analyzed using linear mixed effects models to determine the effect of iTBS (active or sham) on normalized MEPs (nMEPs). iTBS effects were compared to a ratio of active and resting motor thresholds as a measurement of corticomotor conductance potential.

resultsRelative to sham, active iTBS increased nMEPs over time (p < 0.001) in individuals with SCI, but not nonimpaired individuals (p = 0.915). The amplitude of nMEPs were correlated with the biceps corticomotor conductance potential (p < 0.001), with nMEPs decreasing as the ratio increased at different rates after sham or active iTBS.

conclusionsPreliminary results suggest that iTBS increases biceps corticomotor excitability in individuals with tetraplegia with effects that may be predicted by corticomotor conductance potential. Clinical trial registration NCT03277521 Registered on clinicaltrials.gov on August 24, 2017.

Indexed as

Motor CortexSpinal Cord InjuriesArmEvoked Potentials, MotorHumansQuadriplegiaTranscranial Magnetic StimulationMotor evoked potentialsNeuromodulationRehabilitationSpinal cord injuryTranscranial magnetic stimulation

Identifiers

PMID35843943
PMCPMC9290267
OpenAlexW4285676957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.