SynthesisBMC oral health2022
Impact of bisphosphonate drugs on dental implant healing and peri-implant hard and soft tissues: a systematic review.
Synthesis in BMC oral health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- How far can we go? A 20-year meta-analysis of dental implant survival rates.Clinical oral investigations · 2024Pooled it
- Clinical, Immunological and Microbiological Improvements With Zinc-Coated Healing Abutments During the Healing Phase.International dental journal · 2026Trial
- Proposition of a New Scale for Marginal Bone Loss Prediction Around Dental Implants-A 5-Year Follow-Up of Functional Loaded Implants.Diagnostics (Basel, Switzerland) · 2025Article
- The Effect of Varying Abutment Heights on Stress Distribution in Different Bone Densities: A Finite Element Analysis Study.Materials (Basel, Switzerland) · 2025Article
- Optimization of Peri-Implant Bone Repair in Estrogen-Deficient Rats on a Cafeteria Diet: The Combined Effects of Systemic Risedronate and Genistein-Functionalized Implants.Materials (Basel, Switzerland) · 2025Article
- Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies.Frontiers in microbiology · 2025Review
- Review
- Zirconia Dental Implant Designs and Surface Modifications: A Narrative Review.Materials (Basel, Switzerland) · 2024Review
- Bone Metabolism and Dental Implant Insertion as a Correlation Affecting on Marginal Bone Remodeling: Texture Analysis and the New Corticalization Index, Predictor of Marginal Bone Loss-3 Months of Follow-Up.Journal of clinical medicine · 2024Article
- Review
- Effects of the Application Local Zoledronic Acid On Different Dental Implants in Rats On Osseointegration.Drug design, development and therapy · 2024Article
- Assessing dental surgeons' understanding of bisphosphonates: Implications for patient health in oral surgery.The Saudi dental journal · 2024Article
- Bisphosphonates and Their Connection to Dental Procedures: Exploring Bisphosphonate-Related Osteonecrosis of the Jaws.Cancers · 2023Review
- Do Systemic Diseases and Medications Influence Dental Implant Osseointegration and Dental Implant Health? An Umbrella Review.Dentistry journal · 2023Review
- Clinical study to assess influence of immediate provisionalization and various implant morphologies on implant stability: A prospective clinical study.Frontiers in surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveImplantology represents the gold standard for oral rehabilitation, unfortunately, often, despite there are no local contraindications to this type of rehabilitation, there are uncertainties regarding the general health of our patients. Many patients nowadays take bisphosphonate drugs, often without first seeking advice from an oral surgeon or a dentist. The purpose of this review is precisely to highlight any contraindications to this type of treatment reported in the literature, in patients who take or have taken bisphosphonate drugs.
methodsFor this study the scientific information sources were consulted using as search terms "("bisphosphonate AND "dental implant")", obtaining 312 results, these were subsequently skimmed according to the inclusion and exclusion criteria, and further evaluated their relevance to the study and the presence of requested outcomes.
resultsOnly 9 manuscripts (RCTs, Multicentric studies and Clinical Trials) were included in this review, as they respected the parameters of this review, they were analyzed and it was possible to draw important results from them. Surely from this study it is understood that the use of bisphosphonate drugs does not represent an absolute contraindication to implant therapy, it is evident how adequate pharmacological prophylaxis, and an adequate protocol reduce the risks regarding implant failures. Furthermore, the values of marginal bone loss over time seem, even if not statistically significant, to be better in implant rehabilitation with bisphosphonate drugs association. Only a few molecules like risedronate, or corticosteroids, or some conditions like smoking or diabetes have shown a high risk of surgical failure.
conclusionAlthough this study considered different studies for a total of 378 patients and at least 1687 different dental implants, showing better results in some cases for dental implant therapy in cases of bisphosphonate intake, further clinical, randomized and multicentric studies are needed, with longer follow-ups, to fully clarify this situation which often negatively affects the quality of life of our patients and places clinicians in the face of doubts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.