ArticleBiological psychiatry2022
Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis.Molecular psychiatry · 2024Pooled it
- Altered semantic prediction error processing with increasing schizotypal and autistic traits.Translational psychiatry · 2026Article
- Predictive Inference Alterations in Psychosis Proneness Show Task-Dependent Signatures.Annals of the New York Academy of Sciences · 2026Article
- Individual threat-relevance accelerates belief-updating in conditioned hallucinations.Scientific reports · 2026Article
- Hallucination Proneness is Linked to Over-Reliance on Internal Priors for Noisy Speech.Schizophrenia bulletin · 2026Article
- Threading the Needle: Practical Considerations for Merging Theory-Driven Computational Psychiatry With Data-Driven Analytics to Enhance Precision Health at Scale.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Compensatory hallucinogenesis across three neuropsychiatric disorders: a Bayesian account.Brain communications · 2026Review
- Refining mechanistic models of hallucinations for enhanced translatability.Translational psychiatry · 2025Review
- Emergence and Dynamics of Delusions and Hallucinations Across Stages in Early Psychosis.Biological psychiatry · 2025Article
- An ace in the hole? Opportunities and limits of using mice to understand schizophrenia neurobiology.Molecular psychiatry · 2025Review
- The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Empirically Integrating the Evidence for Different Predictive Coding Components Using Auditory False Perception.Human brain mapping · 2025Article
- A Computational Account of the Development and Evolution of Psychotic Symptoms.Biological psychiatry · 2025Review
- Oscillatory signatures of monitoring and anticipatory strategies for probabilistic vs deterministic cues.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Auditory illusory models as proxies to investigate bottom-up and top-down neural networks of phantom perception.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The Future of Perceptual Dysregulation in Psychiatric Nosology.Current topics in behavioral neurosciences · 2025Review
- Dynamic predictive templates in perception.Current biology : CB · 2024Article
- Multisensory perceptual and causal inference is largely preserved in medicated post-acute individuals with schizophrenia.PLoS biology · 2024Article
- Recent social stress and severity of auditory hallucinations.Schizophrenia research · 2024Article
- Article
Corrections and comments
- Commented on by
- Erratum issuedErratum.2022
Authors and funding
18 authors at 8 institutions in 8 countries.
Funding
Abstract
backgroundRecent advances in computational psychiatry have identified latent cognitive and perceptual states that predispose to psychotic symptoms. Behavioral data fit to Bayesian models have demonstrated an overreliance on priors (i.e., prior overweighting) during perception in select samples of individuals with hallucinations, corresponding to increased precision of prior expectations over incoming sensory evidence. However, the clinical utility of this observation depends on the extent to which it reflects static symptom risk or current symptom state.
methodsTo determine whether task performance and estimated prior weighting relate to specific elements of symptom expression, a large, heterogeneous, and deeply phenotyped sample of hallucinators (n = 249) and nonhallucinators (n = 209) performed the conditioned hallucination (CH) task.
resultsWe found that CH rates predicted stable measures of hallucination status (i.e., peak frequency). However, CH rates were more sensitive to hallucination state (i.e., recent frequency), significantly correlating with recent hallucination severity and driven by heightened reliance on past experiences (priors). To further test the sensitivity of CH rate and prior weighting to symptom severity, a subset of participants with hallucinations (n = 40) performed a repeated-measures version of the CH task. Changes in both CH frequency and prior weighting varied with changes in auditory hallucination frequency on follow-up.
conclusionsThese results indicate that CH rate and prior overweighting are state markers of hallucination status, potentially useful in tracking disease development and treatment response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.