Evidence map›Paper›PMID 35843385›Full record

ArticleMolecular and cellular endocrinology2022

Hyponatremia elicits gene expression changes driving osteoclast differentiation and functions.

Julianna Barsony, Qin Xu, Joseph G Verbalis

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Association of hyponatremia with bone mineral density and fractures: a narrative review.Therapeutic advances in endocrinology and metabolism · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Julianna BarsonyDivision of Endocrinology & Metabolism, Georgetown University, Washington, DC, 20007, USA. Electronic address: jb394@georgetown.edu.
Qin XuDivision of Endocrinology & Metabolism, Georgetown University, Washington, DC, 20007, USA.
Joseph G VerbalisDivision of Endocrinology & Metabolism, Georgetown University, Washington, DC, 20007, USA.
Georgetown University · US

Funding

Hyponatremia-Induced Osteoporosis and FragilityR01AG053506 · NIA · GEORGETOWN UNIVERSITY · PI BARSONY, JULIANNA, VERBALIS, JOSEPH G · 2017 to 2021
$1.9M
HYPONATREMIA-INDUCED OSTEOPOROSISR01AG029477 · NIA · GEORGETOWN UNIVERSITY · PI VERBALIS, JOSEPH G · 2008 to 2010
$1.2M
NIA NIH HHS R01 AG029477NIA NIH HHS R01 AG053506
6 · The paper itself

Abstract

Growing evidence indicates that chronic hyponatremia represents a significant risk for bone loss, osteoporosis, and fractures in our aging population. Our prior studies on a rat model of the syndrome of inappropriate antidiuretic hormone secretion indicated that chronic hyponatremia causes osteoporosis by increasing osteoclastic bone resorption, thereby liberating stored sodium from bone. Moreover, studies in RAW264.7 pre-osteoclastic cells showed increased osteoclast formation and resorptive activity in response to low extracellular fluid sodium ion concentration (low [Na

Indexed as

Bone ResorptionHyponatremiaOsteoporosisAnimalsCell DifferentiationGene ExpressionMiceOsteoclastsPhosphatidylinositol 3-KinasesRANK LigandRatsSodiumPhosphatidylinositol 3-KinasesRANK LigandSodiumATP productionGene expressionHyponatremiaLysosomal pathwayMatrix melloproteinase-9MotilityOsteoclast

Identifiers

PMID35843385
PMCPMC10586021
OpenAlexW4285403540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.