Evidence map›Paper›PMID 35843207›Full record

ArticleOphthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde2022

Sex Hormones in Males and Females with Active Central Serous Chorioretinopathy.

Joost Brinks, Elon H C van Dijk, Roula Tsonaka, Onno C Meijer, Camiel J F Boon

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Hormonal factors in the pathophysiology of central serous chorioretinopathy - a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  3. Observational
  4. Article
  5. Pachychoroid disease: review and update.Eye (London, England) · 2025
    Review
  6. Article
  7. Article
  8. Instances of ocular findings in transgender patients undergoing hormonal therapy.American journal of ophthalmology case reports · 2023
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joost BrinksDepartment of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands, j.brinks@lumc.nl.
Elon H C van DijkDepartment of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Roula TsonakaDepartment of Biomedical Data Sciences, Medical Statistics Section, Leiden University Medical Center, Leiden, The Netherlands.
Onno C MeijerDivision of Endocrinology and Metabolism, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Camiel J F BoonDepartment of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the study was to assess the role of sex hormones in male and female patients with central serous chorioretinopathy (CSC), a disease with a pronounced male predilection.

methodsA total of 206 chronic CSC patients (183 males, 23 females) and 59 healthy controls (29 males, 30 females) were enrolled. Serum testosterone, estradiol, albumin, and sex hormone-binding globulin levels were determined using immunoassays. The free fraction of testosterone and the free testosterone/estradiol ratio were calculated.

resultsNo differences in the levels of total testosterone and estradiol were observed between CSC patients and healthy controls. Albumin levels were found to be lower in male CSC patients compared to controls (controls 47.8 g/L, patients 46.0 g/L, adj. p = 0.006). Only in females with CSC, sex hormone-binding globulin levels were found to be lower (controls 94.2 nmol/L, patients 50.4 nmol/L, adj. p = 0.001), together with a higher free testosterone/estradiol ratio (controls 0.06, patients 0.18, adj. p = 0.018).

conclusionsIn this study, we did not find evidence for a disturbance in sex hormone levels in males with CSC. The lower levels of sex hormone-binding globulin in females with CSC, leading to a disturbed free testosterone/estradiol ratio, warrant further investigation into the role of androgens in females with CSC.

Indexed as

Central Serous ChorioretinopathySex Hormone-Binding GlobulinAlbuminsEstradiolFemaleGonadal Steroid HormonesHumansMaleTestosteroneAlbuminsEstradiolGonadal Steroid HormonesSex Hormone-Binding GlobulinTestosteroneCentral serous chorioretinopathySex hormone-binding globulinSex hormonesSteroidsTestosterone

Identifiers

PMID35843207
PMCPMC9909722
OpenAlexW4285594157

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.