Evidence map›Paper›PMID 35843112›Full record

ArticleDiagnostic microbiology and infectious disease2022

Rapid repeat infection of SARS-CoV-2 by two highly distinct delta-lineage viruses.

Andrew J Gorzalski, Christina Boyles, Victoria Sepcic, Subhash Verma, Joel Sevinsky, Kevin Libuit, Stephanie Van Hooser, Mark W Pandori

Abstract readCase Reports
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrew J GorzalskiNevada State Public Health Laboratory, Reno, NV, USA.
Christina BoylesMineral County Park and Recreation, Hawthorne, NV, USA.
Victoria SepcicNevada Department of Health and Human Services, Department of Public and Behavioral Health, Carson City, NV, USA.
Subhash VermaDepartment of Microbiology and Immunology, University of Nevada, School of Medicine, Reno, NV, USA.
Joel SevinskyTheiagen Genomics, Highlands Ranch, CO, USA.
Kevin LibuitTheiagen Genomics, Highlands Ranch, CO, USA.
Stephanie Van HooserNevada State Public Health Laboratory, Reno, NV, USA.
Mark W PandoriNevada State Public Health Laboratory, Reno, NV, USA; Department of Pathology and Laboratory Medicine, University of Nevada, School of Medicine, Reno, NV, USA. Electronic address: mpandori@med.unr.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An instance of sequential infection of an individual with, firstly, the Delta variant and secondly a Delta-sub-lineage has been identified. The individual was found positive for the AY.26 lineage 22 days after being found positive for the Delta [B.1.617.2] variant. The viruses associated with the cases showed dramatic genomic difference, including 31 changes that resulted in deletions or amino acid substitutions. Seven of these differences were observed in the Spike protein. The patient in question was between 30 and 35 years old and had no underlying health conditions. Though singular, this case illustrates the possibility that infection with the Delta variant may not itself be fully protective against a population of SARS-CoV-2 variants that are becoming increasingly diverse.

Indexed as

COVID-19SARS-CoV-2AdultHumansdeltamutationsreinfectionSARS-CoV-2

Identifiers

PMID35843112
PMCPMC9217632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.